A Comparitive Assessement of Cytokine Expression in Human-Derived Cell Lines Exposed to Alpha Particles and X-Rays

Alpha- (α-) particle radiation exposure has been linked to the development of lung cancer and has been identified as a radiation type likely to be employed in radiological dispersal devices. Currently, there exists a knowledge gap concerning cytokine modulations associated with exposure to α-partic...

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Main Authors:	Vinita Chauhan, Matthew Howland, Ruth Wilkins
Format:	Article
Language:	English
Published:	Hindawi Limited 2012-01-01
Series:	The Scientific World Journal
Online Access:	http://dx.doi.org/10.1100/2012/609295

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spelling	doaj-0a68a412096445c1b5dccb085ffa50d82020-11-24T21:25:54ZengHindawi LimitedThe Scientific World Journal1537-744X2012-01-01201210.1100/2012/609295609295A Comparitive Assessement of Cytokine Expression in Human-Derived Cell Lines Exposed to Alpha Particles and X-RaysVinita Chauhan0Matthew Howland1Ruth Wilkins2Consumer and Clinical Radiation Protection Bureau, Health Canada, Ottawa, ON, K1A 0K9, CanadaConsumer and Clinical Radiation Protection Bureau, Health Canada, Ottawa, ON, K1A 0K9, CanadaConsumer and Clinical Radiation Protection Bureau, Health Canada, Ottawa, ON, K1A 0K9, CanadaAlpha- (α-) particle radiation exposure has been linked to the development of lung cancer and has been identified as a radiation type likely to be employed in radiological dispersal devices. Currently, there exists a knowledge gap concerning cytokine modulations associated with exposure to α-particles. Bio-plex technology was employed to investigate changes in proinflammatory cytokines in two human-derived cell lines. Cells were irradiated at a dose of 1.5 Gy to either α-particles or X-rays at equivalent dose rates. The two cell lines exhibited a unique pattern of cytokine expression and the response varied with radiation type. Of the 27 cytokines assessed, only vascular endothelin growth factor (VEGF) was observed to be modulated in both cell lines solely after α-particle exposure, and the expression of VEGF was shown to be dose responsive. These results suggest that certain proinflammatory cytokines may be involved in the biological effects related to α- particle exposure and the responses are cell type and radiation type specific.http://dx.doi.org/10.1100/2012/609295
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Vinita Chauhan Matthew Howland Ruth Wilkins
spellingShingle	Vinita Chauhan Matthew Howland Ruth Wilkins A Comparitive Assessement of Cytokine Expression in Human-Derived Cell Lines Exposed to Alpha Particles and X-Rays The Scientific World Journal
author_facet	Vinita Chauhan Matthew Howland Ruth Wilkins
author_sort	Vinita Chauhan
title	A Comparitive Assessement of Cytokine Expression in Human-Derived Cell Lines Exposed to Alpha Particles and X-Rays
title_short	A Comparitive Assessement of Cytokine Expression in Human-Derived Cell Lines Exposed to Alpha Particles and X-Rays
title_full	A Comparitive Assessement of Cytokine Expression in Human-Derived Cell Lines Exposed to Alpha Particles and X-Rays
title_fullStr	A Comparitive Assessement of Cytokine Expression in Human-Derived Cell Lines Exposed to Alpha Particles and X-Rays
title_full_unstemmed	A Comparitive Assessement of Cytokine Expression in Human-Derived Cell Lines Exposed to Alpha Particles and X-Rays
title_sort	comparitive assessement of cytokine expression in human-derived cell lines exposed to alpha particles and x-rays
publisher	Hindawi Limited
series	The Scientific World Journal
issn	1537-744X
publishDate	2012-01-01
description	Alpha- (α-) particle radiation exposure has been linked to the development of lung cancer and has been identified as a radiation type likely to be employed in radiological dispersal devices. Currently, there exists a knowledge gap concerning cytokine modulations associated with exposure to α-particles. Bio-plex technology was employed to investigate changes in proinflammatory cytokines in two human-derived cell lines. Cells were irradiated at a dose of 1.5 Gy to either α-particles or X-rays at equivalent dose rates. The two cell lines exhibited a unique pattern of cytokine expression and the response varied with radiation type. Of the 27 cytokines assessed, only vascular endothelin growth factor (VEGF) was observed to be modulated in both cell lines solely after α-particle exposure, and the expression of VEGF was shown to be dose responsive. These results suggest that certain proinflammatory cytokines may be involved in the biological effects related to α- particle exposure and the responses are cell type and radiation type specific.
url	http://dx.doi.org/10.1100/2012/609295
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A Comparitive Assessement of Cytokine Expression in Human-Derived Cell Lines Exposed to Alpha Particles and X-Rays

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