TrkB mediates BDNF-induced potentiation of neuronal necrosis in cortical culture

TrkB mediates BDNF-induced potentiation of neuronal necrosis in cortical culture

In the present study, the signaling mechanisms underlying the effect of brain-derived neurotrophic factor (BDNF) on neuronal necrosis were investigated. Exposure of mature mouse cortical cultures (more than 10 days in vitro (DIV)) to 50–100 ng/ml BDNF for 48 h induced widespread neuronal necrosis th...

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Bibliographic Details
Main Authors: Hyun-Jung Kim, Jung Jin Hwang, M.Margarita Behrens, B.Joy Snider, Dennis W Choi, Jae-Young Koh
Format: Article
Language:English
Published: Elsevier 2003-10-01
Series:Neurobiology of Disease
Subjects:
Neurotrophin
Oxidative stress
Cell death, p75NTR
Erk
TrkB knockout
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996103001037

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