C-terminal fluorescent labeling impairs functionality of DNA mismatch repair proteins.

C-terminal fluorescent labeling impairs functionality of DNA mismatch repair proteins.

The human DNA mismatch repair (MMR) process is crucial to maintain the integrity of the genome and requires many different proteins which interact perfectly and coordinated. Germline mutations in MMR genes are responsible for the development of the hereditary form of colorectal cancer called Lynch s...

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Bibliographic Details
Main Authors: Angela Brieger, Guido Plotz, Inga Hinrichsen, Sandra Passmann, Ronja Adam, Stefan Zeuzem
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3279419?pdf=render

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