Radiation-Induced Damage to Prepubertal Pax7+ Skeletal Muscle Stem Cells Drives Lifelong Deficits in Myofiber Size and Nuclear Number

Radiation-Induced Damage to Prepubertal Pax7+ Skeletal Muscle Stem Cells Drives Lifelong Deficits in Myofiber Size and Nuclear Number

Summary: During prepubertal development, muscle stem cells (satellite cells, SCs) actively contribute to myofiber growth. Because some SCs are active during this time, they may be particularly susceptible to damage. Using a Small Animal Radiation Research Platform (SARRP), we investigated the effect...

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Bibliographic Details
Main Authors: John F. Bachman, Roméo S. Blanc, Nicole D. Paris, Jacob G. Kallenbach, Carl J. Johnston, Eric Hernady, Jacqueline P. Williams, Joe V. Chakkalakal
Format: Article
Language:English
Published: Elsevier 2020-11-01
Series:iScience
Subjects:
Cell Biology
Stem Cell Research
Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220309573

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