SYNTHESIS, CHARACTERIZATION AND ANTITUMOR ACTIVITY OF A Ca (II) COORDINATION POLYMER BASED ON 3-AMINO-2-PYRAZINECARBOXYLIC ACID

• Main Authors: XI-SHI TAI, XIN WANG
• Format: Article
• Language: English
• Published: Alma Mater Publishing House "Vasile Alecsandri" University of Bacau 2015-10-01
• Series: Scientific Study & Research: Chemistry & Chemical Engineering, Biotechnology, Food Industry
• Subjects: 3-amino-2-pyrazinecarboxylic acid; antitumor activity; Ca(II) coordination polymer; structural characterization
• Online Access: http://pubs.ub.ro/?pg=revues&rev=cscc6&num=201503&vol=3&aid=4302

A new Ca(II) coordination polymer has been obtained by reaction of Ca(ClO4)2·H2O with 3-amino-2-pyrazinecarboxylic acid in CH3CH2OH/H2O. It was characterized by IR, 1HNMR, thermal analysis and X-ray single crystal diffraction analysis. X-ray analysis reveals that each Ca(II) center is seven-coordination with a N2O5 distorted pentagonal bipyramidal coordination environment. The Ca(II) ions are linked through the O atoms of 3-amino-2-pyrazinecarboxylic acid ligands to form 1D chain structure. And then a 3D network structure is constructed by hydrogen bonds and π-π stacking. The antitumor activity of 3-amino-2-pyrazinecarboxylic acid ligand and its Ca(II) coordination polymer against human intestinal adenocarcinoma HCT-8 cells, lung adenocarcinoma HCT-116 cells and human lung adenocarcinoma A549 cells line have been investigated.