SYNTHESIS, CHARACTERIZATION AND ANTITUMOR ACTIVITY OF A Ca (II) COORDINATION POLYMER BASED ON 3-AMINO-2-PYRAZINECARBOXYLIC ACID
A new Ca(II) coordination polymer has been obtained by reaction of Ca(ClO4)2·H2O with 3-amino-2-pyrazinecarboxylic acid in CH3CH2OH/H2O. It was characterized by IR, 1HNMR, thermal analysis and X-ray single crystal diffraction analysis. X-ray analysis reveals that each Ca(II) center is seven-coordina...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Alma Mater Publishing House "Vasile Alecsandri" University of Bacau
2015-10-01
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| Series: | Scientific Study & Research: Chemistry & Chemical Engineering, Biotechnology, Food Industry |
| Subjects: | |
| Online Access: | http://pubs.ub.ro/?pg=revues&rev=cscc6&num=201503&vol=3&aid=4302 |
| Summary: | A new Ca(II) coordination polymer has been obtained by reaction of Ca(ClO4)2·H2O with 3-amino-2-pyrazinecarboxylic acid in CH3CH2OH/H2O. It was characterized by IR, 1HNMR, thermal analysis and X-ray single crystal diffraction analysis. X-ray analysis reveals that each Ca(II) center is seven-coordination with a N2O5 distorted pentagonal bipyramidal coordination environment. The Ca(II) ions are linked through the O atoms of 3-amino-2-pyrazinecarboxylic acid ligands to form 1D chain structure. And then a 3D network structure is constructed by hydrogen bonds and π-π stacking. The antitumor activity of 3-amino-2-pyrazinecarboxylic acid ligand and its Ca(II) coordination polymer against human intestinal adenocarcinoma HCT-8 cells, lung adenocarcinoma HCT-116 cells and human lung adenocarcinoma A549 cells line have been investigated. |
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| ISSN: | 1582-540X 1582-540X |