In Vitro and In Silico Analyses of Nicotine Release from a Gelisphere-Loaded Compressed Polymeric Matrix for Potential Parkinson’s Disease Interventions

In Vitro and In Silico Analyses of Nicotine Release from a Gelisphere-Loaded Compressed Polymeric Matrix for Potential Parkinson’s Disease Interventions

This study aimed to develop a prolonged-release device for the potential site-specific delivery of a neuroprotective agent (nicotine). The device was formulated as a novel reinforced crosslinked composite polymeric system with the potential for intrastriatal implantation in Parkinson’s dis...

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Bibliographic Details
Main Authors: Pradeep Kumar, Yahya E. Choonara, Lisa C. du Toit, Neha Singh, Viness Pillay
Format: Article
Language:English
Published: MDPI AG 2018-11-01
Series:Pharmaceutics
Subjects:
alginate gelispheres
textural analysis
crosslinked matrices
PLGA discs
prolonged release
powder flow properties
Online Access:https://www.mdpi.com/1999-4923/10/4/233

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