Effect of acupuncture intervention on the intestinal mucosal inflammatory response and immune response balance in animals with ulcerative colitis
Objective: To study the effect of acupuncture intervention on the intestinal mucosal inflammatory response and immune response balance in animals with ulcerative colitis (UC). Methods: Adult, male SPF SD rats were selected and randomly divided into the control group, UC group and acupuncture grou...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Editorial Board of Journal of Hainan Medical University
2017-07-01
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| Series: | Journal of Hainan Medical University |
| Subjects: | |
| Online Access: | http://www.hnykdxxb.com/PDF/201713/3.pdf |
| Summary: | Objective: To study the effect of acupuncture intervention on the intestinal mucosal
inflammatory response and immune response balance in animals with ulcerative colitis
(UC). Methods: Adult, male SPF SD rats were selected and randomly divided into the
control group, UC group and acupuncture group, and then the acupuncture intervention was
established after the UC animal model was established. 14 d after intervention, the expression
of inflammatory mediators and Th1/Th2/Th17/Treg cytokines in intestinal mucosa, and the
levels of inflammatory mediators and Th1/Th2/Th17/Treg cytokines in serum were detected.
Results: NF-kB, HMGB-1, TNF-α, IL-1β, IFN-γ and IL-17 mRNA expression in intestinal
mucosa as well as HMGB-1, TNF-α, IL-1β, IFN-γ and IL-17 levels in serum of UC group
were significantly higher than those of control group while IL-4, IL-5 and TGF-β1 mRNA
expression in intestinal mucosa as well as IL-4, IL-5 and TGF-β1 levels in serum were
significantly lower than those of control group; NF-kB, HMGB-1, TNF-α, IL-1β, IFN-γ
and IL-17 mRNA expression in intestinal mucosa as well as HMGB-1, TNF-α, IL-1β,
IFN-γ and IL-17 levels in serum of acupuncture group were significantly lower than those
of UC group while IL-4, IL-5 and TGF-β1 mRNA expression in intestinal mucosa as well
as IL-4, IL-5 and TGF-β1 levels in serum were significantly higher than those of UC group.
Conclusions: Acupuncture intervention can regulate the intestinal mucosal inflammatory
response and immune response of animals with ulcerative colitis. |
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| ISSN: | 1007-1237 1007-1237 |