Composite Materials Design: Biomineralization Proteins and the Guided Assembly and Organization of Biomineral Nanoparticles

• Main Author: John Spencer Evans
• Format: Article
• Language: English
• Published: MDPI AG 2019-02-01
• Series: Materials
• Subjects: biomineralization; mesocrystal; nanoparticles; particle attachment; proteomics; nucleation; biocomposites; hydrogels
• Online Access: https://www.mdpi.com/1996-1944/12/4/581

There has been much discussion of the role of proteins in the calcium carbonate biomineralization process, particularly with regard to nucleation, amorphous stabilization/transformation, and polymorph selection. However, there has been little if any discussion of the potential role that proteins might play in another important process: the guided assembly and organization of mineral nanoparticles into higher-ordered structures such as mesocrystals. This review discusses particle attachment theory and recent evidence of mineral-associated proteins forming hydrogels that assemble and organize mineral clusters into crystalline phase. From this discussion we postulate a mechanism by which biomineralization protein hydrogel aggregation assists in mineral nanoparticle assembly and organization within calcium carbonate skeletal elements and discuss potentials ways for harnessing this process in materials design.