Dysfunction of Protein Quality Control in Parkinsonism–Dementia Complex of Guam

Guam parkinsonism–dementia complex (G-PDC) is an enigmatic neurodegenerative disease that is endemic to the Pacific island of Guam. G-PDC patients are clinically characterized by progressive cognitive impairment and parkinsonism. Neuropathologically, G-PDC is characterized by abundant neurofibrillar...

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Bibliographic Details
Main Authors: Bert M. Verheijen, Kiyomitsu Oyanagi, Fred W. van Leeuwen
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Neurology
Subjects:
tau
Online Access:http://journal.frontiersin.org/article/10.3389/fneur.2018.00173/full