SARS-CoV-2 specific antibody and neutralization assays reveal the wide range of the humoral immune response to virus

SARS-CoV-2 specific antibody and neutralization assays reveal the wide range of the humoral immune response to virus

Using SARS-CoV-2-specific antibody- and neutralization assays, Dogan et al find that hospitalized individuals show higher IgG antibody responses and higher neutralization titers compared to outpatient or convalescent plasma donors, providing insights into the host humoral response to SARS CoV-2.

Bibliographic Details
Main Authors: Mikail Dogan, Lina Kozhaya, Lindsey Placek, Courtney Gunter, Mesut Yigit, Rachel Hardy, Matthew Plassmeyer, Paige Coatney, Kimberleigh Lillard, Zaheer Bukhari, Michael Kleinberg, Chelsea Hayes, Moshe Arditi, Ellen Klapper, Noah Merin, Bruce Tsan-Tang Liang, Raavi Gupta, Oral Alpan, Derya Unutmaz
Format: Article
Language:English
Published: Nature Publishing Group 2021-01-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-021-01649-6
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spelling doaj-0a236342fbca4be7ad7450120dc25e6b2021-01-31T16:16:20ZengNature Publishing GroupCommunications Biology2399-36422021-01-014111310.1038/s42003-021-01649-6SARS-CoV-2 specific antibody and neutralization assays reveal the wide range of the humoral immune response to virusMikail Dogan0Lina Kozhaya1Lindsey Placek2Courtney Gunter3Mesut Yigit4Rachel Hardy5Matthew Plassmeyer6Paige Coatney7Kimberleigh Lillard8Zaheer Bukhari9Michael Kleinberg10Chelsea Hayes11Moshe Arditi12Ellen Klapper13Noah Merin14Bruce Tsan-Tang Liang15Raavi Gupta16Oral Alpan17Derya Unutmaz18Jackson Laboratory for Genomic MedicineJackson Laboratory for Genomic MedicineJackson Laboratory for Genomic MedicineJackson Laboratory for Genomic MedicineJackson Laboratory for Genomic MedicineJackson Laboratory for Genomic MedicineAmerimmuneAmerimmuneAmerimmuneSUNY Downstate Medical Center, Department of PathologyCalhoun Cardiology Center, University of Connecticut School of MedicineDepartment of Pathology & Laboratory Medicine and Transfusion Medicine, Cedars-Sinai Medical CenterDepartment of Pediatric, Division of Pediatric Infectious Diseases and Immunology, Biomedical Sciences, Cedars-Sinai Medical CenterDepartment of Pathology & Laboratory Medicine and Transfusion Medicine, Cedars-Sinai Medical CenterDepartment of Internal Medicine, Division of Hematology Cedars-Sinai Medical CenterCalhoun Cardiology Center, University of Connecticut School of MedicineSUNY Downstate Medical Center, Department of PathologyAmerimmuneJackson Laboratory for Genomic MedicineUsing SARS-CoV-2-specific antibody- and neutralization assays, Dogan et al find that hospitalized individuals show higher IgG antibody responses and higher neutralization titers compared to outpatient or convalescent plasma donors, providing insights into the host humoral response to SARS CoV-2.https://doi.org/10.1038/s42003-021-01649-6
collection DOAJ
language English
format Article
sources DOAJ
author Mikail Dogan
Lina Kozhaya
Lindsey Placek
Courtney Gunter
Mesut Yigit
Rachel Hardy
Matthew Plassmeyer
Paige Coatney
Kimberleigh Lillard
Zaheer Bukhari
Michael Kleinberg
Chelsea Hayes
Moshe Arditi
Ellen Klapper
Noah Merin
Bruce Tsan-Tang Liang
Raavi Gupta
Oral Alpan
Derya Unutmaz
spellingShingle Mikail Dogan
Lina Kozhaya
Lindsey Placek
Courtney Gunter
Mesut Yigit
Rachel Hardy
Matthew Plassmeyer
Paige Coatney
Kimberleigh Lillard
Zaheer Bukhari
Michael Kleinberg
Chelsea Hayes
Moshe Arditi
Ellen Klapper
Noah Merin
Bruce Tsan-Tang Liang
Raavi Gupta
Oral Alpan
Derya Unutmaz
SARS-CoV-2 specific antibody and neutralization assays reveal the wide range of the humoral immune response to virus
Communications Biology
author_facet Mikail Dogan
Lina Kozhaya
Lindsey Placek
Courtney Gunter
Mesut Yigit
Rachel Hardy
Matthew Plassmeyer
Paige Coatney
Kimberleigh Lillard
Zaheer Bukhari
Michael Kleinberg
Chelsea Hayes
Moshe Arditi
Ellen Klapper
Noah Merin
Bruce Tsan-Tang Liang
Raavi Gupta
Oral Alpan
Derya Unutmaz
author_sort Mikail Dogan
title SARS-CoV-2 specific antibody and neutralization assays reveal the wide range of the humoral immune response to virus
title_short SARS-CoV-2 specific antibody and neutralization assays reveal the wide range of the humoral immune response to virus
title_full SARS-CoV-2 specific antibody and neutralization assays reveal the wide range of the humoral immune response to virus
title_fullStr SARS-CoV-2 specific antibody and neutralization assays reveal the wide range of the humoral immune response to virus
title_full_unstemmed SARS-CoV-2 specific antibody and neutralization assays reveal the wide range of the humoral immune response to virus
title_sort sars-cov-2 specific antibody and neutralization assays reveal the wide range of the humoral immune response to virus
publisher Nature Publishing Group
series Communications Biology
issn 2399-3642
publishDate 2021-01-01
description Using SARS-CoV-2-specific antibody- and neutralization assays, Dogan et al find that hospitalized individuals show higher IgG antibody responses and higher neutralization titers compared to outpatient or convalescent plasma donors, providing insights into the host humoral response to SARS CoV-2.
url https://doi.org/10.1038/s42003-021-01649-6
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