Ezrin activation by LOK phosphorylation involves a PIP2-dependent wedge mechanism

Ezrin activation by LOK phosphorylation involves a PIP2-dependent wedge mechanism

How cells specify morphologically distinct plasma membrane domains is poorly understood. Prior work has shown that restriction of microvilli to the apical aspect of epithelial cells requires the localized activation of the membrane-F-actin linking protein ezrin. Using an in vitro system, we now defi...

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Bibliographic Details
Main Authors: Thaher Pelaseyed, Raghuvir Viswanatha, Cécile Sauvanet, Joshua J Filter, Michael L Goldberg, Anthony Bretscher
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-04-01
Series:eLife
Subjects:
Microvilli
Cell polarity
Ezrin
LOK
SLK
Online Access:https://elifesciences.org/articles/22759

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