A distinct biomarker of continuous transcutaneous vagus nerve stimulation treatment in major depressive disorder
Background: Major depression is the fourth leading cause of disability worldwide and poses a socioeconomic burden worldwide. Transcutaneous vagus nerve stimulation (tVNS) is a promising noninvasive clinical device that may reduce the severity of major depression. However, the neural mechanism underl...
Main Authors: | , , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2018-05-01
|
Series: | Brain Stimulation |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S1935861X18300342 |
id |
doaj-0a19b432206a41febd97f3041d8b9958 |
---|---|
record_format |
Article |
spelling |
doaj-0a19b432206a41febd97f3041d8b99582021-03-19T07:11:37ZengElsevierBrain Stimulation1935-861X2018-05-01113501508A distinct biomarker of continuous transcutaneous vagus nerve stimulation treatment in major depressive disorderYiheng Tu0Jiliang Fang1Jin Cao2Zengjian Wang3Joel Park4Kristen Jorgenson5Courtney Lang6Jun Liu7Guolei Zhang8Yanping Zhao9Bing Zhu10Peijing Rong11Jian Kong12Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USAGuang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaDepartment of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA; School of Acupuncture Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing, ChinaDepartment of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USADepartment of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USADepartment of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USADepartment of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USAGuang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaGuang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaGuang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaInstitution of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, ChinaInstitution of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, China; Corresponding author. Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, No 16. Dongzhimen Nan Xiao Street, Dongcheng District, Beijing 100700, China.Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA; Corresponding author. Psychiatry Department, Massachusetts General Hospital, Harvard Medical School, Building 120, 2nd Ave, Suite 101C, Charlestown, MA 02129, USA.Background: Major depression is the fourth leading cause of disability worldwide and poses a socioeconomic burden worldwide. Transcutaneous vagus nerve stimulation (tVNS) is a promising noninvasive clinical device that may reduce the severity of major depression. However, the neural mechanism underlying continuous tVNS has not yet been elucidated. Objective: We aimed to explore the effect of hypothalamic subregion functional connectivity (FC) changes during continuous tVNS treatment on major depressive disorder (MDD) patients and to identify the potential biomarkers for treatment outcomes. Methods: Forty-one mild to moderate MDD patients were recruited and received either real or sham tVNS treatment for 4 weeks. We used a seed-to-whole brain approach to estimate the FC changes of hypothalamic subregions and their surrounding control areas during continuous tVNS treatment and explored their association with clinical outcome changes after 4 weeks of treatment. Results: Of the thirty-six patients that completed the study, those in the tVNS group had significantly lower scores on the 24-item Hamilton Depression (HAM-D) Rating Scale compared to the sham tVNS group after 4 weeks of treatment. The FC between the bilateral medial hypothalamus (MH) and rostral anterior cingulate cortex (rACC) was significantly decreased during tVNS but not during sham tVNS. The strength of this FC was significantly correlated with HAM-D improvements after 4 weeks of tVNS. Conclusion: The FC between the bilateral MH and rACC may serve as a potential biomarker for the tVNS state and predict treatment responses. Our results provide insights into the neural modulation mechanisms of continuous tVNS and reveal a potential therapeutic target for MDD patients.http://www.sciencedirect.com/science/article/pii/S1935861X18300342Major depressive disorderHypothalamusRostral anterior cingulate cortexFunctional connectivityBiomarkerTranscutaneous vagus nerve stimulation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yiheng Tu Jiliang Fang Jin Cao Zengjian Wang Joel Park Kristen Jorgenson Courtney Lang Jun Liu Guolei Zhang Yanping Zhao Bing Zhu Peijing Rong Jian Kong |
spellingShingle |
Yiheng Tu Jiliang Fang Jin Cao Zengjian Wang Joel Park Kristen Jorgenson Courtney Lang Jun Liu Guolei Zhang Yanping Zhao Bing Zhu Peijing Rong Jian Kong A distinct biomarker of continuous transcutaneous vagus nerve stimulation treatment in major depressive disorder Brain Stimulation Major depressive disorder Hypothalamus Rostral anterior cingulate cortex Functional connectivity Biomarker Transcutaneous vagus nerve stimulation |
author_facet |
Yiheng Tu Jiliang Fang Jin Cao Zengjian Wang Joel Park Kristen Jorgenson Courtney Lang Jun Liu Guolei Zhang Yanping Zhao Bing Zhu Peijing Rong Jian Kong |
author_sort |
Yiheng Tu |
title |
A distinct biomarker of continuous transcutaneous vagus nerve stimulation treatment in major depressive disorder |
title_short |
A distinct biomarker of continuous transcutaneous vagus nerve stimulation treatment in major depressive disorder |
title_full |
A distinct biomarker of continuous transcutaneous vagus nerve stimulation treatment in major depressive disorder |
title_fullStr |
A distinct biomarker of continuous transcutaneous vagus nerve stimulation treatment in major depressive disorder |
title_full_unstemmed |
A distinct biomarker of continuous transcutaneous vagus nerve stimulation treatment in major depressive disorder |
title_sort |
distinct biomarker of continuous transcutaneous vagus nerve stimulation treatment in major depressive disorder |
publisher |
Elsevier |
series |
Brain Stimulation |
issn |
1935-861X |
publishDate |
2018-05-01 |
description |
Background: Major depression is the fourth leading cause of disability worldwide and poses a socioeconomic burden worldwide. Transcutaneous vagus nerve stimulation (tVNS) is a promising noninvasive clinical device that may reduce the severity of major depression. However, the neural mechanism underlying continuous tVNS has not yet been elucidated. Objective: We aimed to explore the effect of hypothalamic subregion functional connectivity (FC) changes during continuous tVNS treatment on major depressive disorder (MDD) patients and to identify the potential biomarkers for treatment outcomes. Methods: Forty-one mild to moderate MDD patients were recruited and received either real or sham tVNS treatment for 4 weeks. We used a seed-to-whole brain approach to estimate the FC changes of hypothalamic subregions and their surrounding control areas during continuous tVNS treatment and explored their association with clinical outcome changes after 4 weeks of treatment. Results: Of the thirty-six patients that completed the study, those in the tVNS group had significantly lower scores on the 24-item Hamilton Depression (HAM-D) Rating Scale compared to the sham tVNS group after 4 weeks of treatment. The FC between the bilateral medial hypothalamus (MH) and rostral anterior cingulate cortex (rACC) was significantly decreased during tVNS but not during sham tVNS. The strength of this FC was significantly correlated with HAM-D improvements after 4 weeks of tVNS. Conclusion: The FC between the bilateral MH and rACC may serve as a potential biomarker for the tVNS state and predict treatment responses. Our results provide insights into the neural modulation mechanisms of continuous tVNS and reveal a potential therapeutic target for MDD patients. |
topic |
Major depressive disorder Hypothalamus Rostral anterior cingulate cortex Functional connectivity Biomarker Transcutaneous vagus nerve stimulation |
url |
http://www.sciencedirect.com/science/article/pii/S1935861X18300342 |
work_keys_str_mv |
AT yihengtu adistinctbiomarkerofcontinuoustranscutaneousvagusnervestimulationtreatmentinmajordepressivedisorder AT jiliangfang adistinctbiomarkerofcontinuoustranscutaneousvagusnervestimulationtreatmentinmajordepressivedisorder AT jincao adistinctbiomarkerofcontinuoustranscutaneousvagusnervestimulationtreatmentinmajordepressivedisorder AT zengjianwang adistinctbiomarkerofcontinuoustranscutaneousvagusnervestimulationtreatmentinmajordepressivedisorder AT joelpark adistinctbiomarkerofcontinuoustranscutaneousvagusnervestimulationtreatmentinmajordepressivedisorder AT kristenjorgenson adistinctbiomarkerofcontinuoustranscutaneousvagusnervestimulationtreatmentinmajordepressivedisorder AT courtneylang adistinctbiomarkerofcontinuoustranscutaneousvagusnervestimulationtreatmentinmajordepressivedisorder AT junliu adistinctbiomarkerofcontinuoustranscutaneousvagusnervestimulationtreatmentinmajordepressivedisorder AT guoleizhang adistinctbiomarkerofcontinuoustranscutaneousvagusnervestimulationtreatmentinmajordepressivedisorder AT yanpingzhao adistinctbiomarkerofcontinuoustranscutaneousvagusnervestimulationtreatmentinmajordepressivedisorder AT bingzhu adistinctbiomarkerofcontinuoustranscutaneousvagusnervestimulationtreatmentinmajordepressivedisorder AT peijingrong adistinctbiomarkerofcontinuoustranscutaneousvagusnervestimulationtreatmentinmajordepressivedisorder AT jiankong adistinctbiomarkerofcontinuoustranscutaneousvagusnervestimulationtreatmentinmajordepressivedisorder AT yihengtu distinctbiomarkerofcontinuoustranscutaneousvagusnervestimulationtreatmentinmajordepressivedisorder AT jiliangfang distinctbiomarkerofcontinuoustranscutaneousvagusnervestimulationtreatmentinmajordepressivedisorder AT jincao distinctbiomarkerofcontinuoustranscutaneousvagusnervestimulationtreatmentinmajordepressivedisorder AT zengjianwang distinctbiomarkerofcontinuoustranscutaneousvagusnervestimulationtreatmentinmajordepressivedisorder AT joelpark distinctbiomarkerofcontinuoustranscutaneousvagusnervestimulationtreatmentinmajordepressivedisorder AT kristenjorgenson distinctbiomarkerofcontinuoustranscutaneousvagusnervestimulationtreatmentinmajordepressivedisorder AT courtneylang distinctbiomarkerofcontinuoustranscutaneousvagusnervestimulationtreatmentinmajordepressivedisorder AT junliu distinctbiomarkerofcontinuoustranscutaneousvagusnervestimulationtreatmentinmajordepressivedisorder AT guoleizhang distinctbiomarkerofcontinuoustranscutaneousvagusnervestimulationtreatmentinmajordepressivedisorder AT yanpingzhao distinctbiomarkerofcontinuoustranscutaneousvagusnervestimulationtreatmentinmajordepressivedisorder AT bingzhu distinctbiomarkerofcontinuoustranscutaneousvagusnervestimulationtreatmentinmajordepressivedisorder AT peijingrong distinctbiomarkerofcontinuoustranscutaneousvagusnervestimulationtreatmentinmajordepressivedisorder AT jiankong distinctbiomarkerofcontinuoustranscutaneousvagusnervestimulationtreatmentinmajordepressivedisorder |
_version_ |
1724214142264410112 |