Synthesis, anticancer and apoptosis-inducing activities of quinazoline–isatin conjugates: epidermal growth factor receptor-tyrosine kinase assay and molecular docking studies

Synthesis, anticancer and apoptosis-inducing activities of quinazoline–isatin conjugates: epidermal growth factor receptor-tyrosine kinase assay and molecular docking studies

A new series of quinazolinone compounds 16–34 incorporating isatin moieties was synthesized. The antitumor efficacy of the compounds against MDA-MB-231, a breast cancer cell line, and LOVO, a colon cancer cell line, was assessed. Compounds 20, 21, 22, 23, 25, 27, 28, 29, 30, 31, 32, 33, and 34 displ...

Full description

Bibliographic Details
Main Authors: Adel S. El-Azab, Abdullah Al-Dhfyan, Alaa A.-M. Abdel-Aziz, Laila A. Abou-Zeid, Hamad M. Alkahtani, Abdulrahman M. Al-Obaid, Manal A. Al-Gendy
Format: Article
Language:English
Published: Taylor & Francis Group 2017-01-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
Synthesis
isatin
quinazolinone
antitumor
EGFR-TK
molecular docking
Online Access:http://dx.doi.org/10.1080/14756366.2017.1344981

Internet

http://dx.doi.org/10.1080/14756366.2017.1344981

Similar Items