Short-Term Microbiota Manipulation and Forearm Substrate Metabolism in Obese Men: A Randomized, Double-Blind, Placebo-Controlled Trial

Short-Term Microbiota Manipulation and Forearm Substrate Metabolism in Obese Men: A Randomized, Double-Blind, Placebo-Controlled Trial

Objective: To investigate the impact of gut microbiota manipulation on fasting and postprandial skeletal muscle metabolism in humans. Methods: 40 obese, insulin-resistant males were randomized to amoxicillin (broad-spectrum antibiotic), vancomycin (narrow-spectrum antibiotic), or placebo (7 days, 1,...

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Bibliographic Details
Main Authors: Dorien Reijnders, Gijs H. Goossens, Gerben D.A. Hermes, Hauke Smidt, Erwin G. Zoetendal, Ellen E. Blaak
Format: Article
Language:English
Published: Karger Publishers 2018-08-01
Series:Obesity Facts
Subjects:
Microbiota
Skeletal muscle
Obesity
Insulin resistance
Antibiotics
Online Access:https://www.karger.com/Article/FullText/492114

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