Bone Marrow Suppression by c-Kit Blockade Enhances Tumor Growth of Colorectal Metastases through the Action of Stromal Cell-Derived Factor-1

Bone Marrow Suppression by c-Kit Blockade Enhances Tumor Growth of Colorectal Metastases through the Action of Stromal Cell-Derived Factor-1

Background. Mobilization of c-Kit+ hematopoietic cells (HCs) contributes to tumor vascularization. Whereas survival and proliferation of HCs are regulated by binding of the stem cell factor to its receptor c-Kit, migration of HCs is directed by stromal cell-derived factor (SDF)-1. Therefore, targeti...

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Bibliographic Details
Main Authors: Kathrin Rupertus, Gudrun C. Y. Haberl, Claudia Scheuer, Michael D. Menger, Martin K. Schilling, Otto Kollmar
Format: Article
Language:English
Published: Hindawi Limited 2012-01-01
Series:Journal of Oncology
Online Access:http://dx.doi.org/10.1155/2012/196957

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