Identification of unstable network modules reveals disease modules associated with the progression of Alzheimer's disease.

Alzheimer's disease (AD), the most common cause of dementia, is associated with aging, and it leads to neuron death. Deposits of amyloid β and aberrantly phosphorylated tau protein are known as pathological hallmarks of AD, but the underlying mechanisms have not yet been revealed. A high-throug...

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Bibliographic Details
Main Authors: Masataka Kikuchi, Soichi Ogishima, Tadashi Miyamoto, Akinori Miyashita, Ryozo Kuwano, Jun Nakaya, Hiroshi Tanaka
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3858171?pdf=render