Molecular and Mechanistic Characterization of PddB, the First PLP-Independent 2,4-Diaminobutyric Acid Racemase Discovered in an Actinobacterial D-Amino Acid Homopolymer Biosynthesis

Molecular and Mechanistic Characterization of PddB, the First PLP-Independent 2,4-Diaminobutyric Acid Racemase Discovered in an Actinobacterial D-Amino Acid Homopolymer Biosynthesis

We recently disclosed that the biosynthesis of antiviral γ-poly-D-2,4-diaminobutyric acid (poly-D-Dab) in Streptoalloteichus hindustanus involves an unprecedented cofactor independent stereoinversion of Dab catalyzed by PddB, which shows weak homology to diaminopimelate epimerase (DapF). Enzymologic...

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Bibliographic Details
Main Authors: Kazuya Yamanaka, Ryo Ozaki, Yoshimitsu Hamano, Tadao Oikawa
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Microbiology
Subjects:
D-amino acid
PLP-independent
diaminopimelate epimerase
secondary metabolite
biosynthesis
homo poly-amino acid
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2021.686023/full

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https://www.frontiersin.org/articles/10.3389/fmicb.2021.686023/full

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