Peroxisome Proliferator-Activated Receptors Protect against Apoptosis via 14-3-3

Peroxisome Proliferator-Activated Receptors Protect against Apoptosis via 14-3-3

Peroxisome proliferator-activated receptors (PPARs) were reported to prevent cells from stress-induced apoptosis and protect tissues against ischemia-reperfusion injury. The underlying transcriptional mechanism is unclear. Recent reports indicate that the antiapoptotic actions of ligand-activated PP...

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Main Author: Kenneth K. Wu
Format: Article
Language:English
Published: Hindawi Limited 2010-01-01
Series:PPAR Research
Online Access:http://dx.doi.org/10.1155/2010/417646
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spelling doaj-09de3bc4aa164fc3a3dffbc709ed199a2020-11-24T23:14:53ZengHindawi LimitedPPAR Research1687-47571687-47652010-01-01201010.1155/2010/417646417646Peroxisome Proliferator-Activated Receptors Protect against Apoptosis via 14-3-3Kenneth K. Wu0Institute of Cellular and System Medicine, National Health Research Institutes, 35 Keyan Road, Zhunan, Miaoli County 350, TaiwanPeroxisome proliferator-activated receptors (PPARs) were reported to prevent cells from stress-induced apoptosis and protect tissues against ischemia-reperfusion injury. The underlying transcriptional mechanism is unclear. Recent reports indicate that the antiapoptotic actions of ligand-activated PPARδ and PPARγ are mediated through enhanced binding of PPAR to the promoter of 14-3-3ε and upregulation of 14-3-3ε expression. We propose that ligand-activated PPARα exerts its anti-apoptotic actions via the identical pathway. The PPAR to 14-3-3 transcriptional axis plays an important role in protection of cell and tissue integrity and is a target for drug discovery.http://dx.doi.org/10.1155/2010/417646
collection DOAJ
language English
format Article
sources DOAJ
author Kenneth K. Wu
spellingShingle Kenneth K. Wu
Peroxisome Proliferator-Activated Receptors Protect against Apoptosis via 14-3-3
PPAR Research
author_facet Kenneth K. Wu
author_sort Kenneth K. Wu
title Peroxisome Proliferator-Activated Receptors Protect against Apoptosis via 14-3-3
title_short Peroxisome Proliferator-Activated Receptors Protect against Apoptosis via 14-3-3
title_full Peroxisome Proliferator-Activated Receptors Protect against Apoptosis via 14-3-3
title_fullStr Peroxisome Proliferator-Activated Receptors Protect against Apoptosis via 14-3-3
title_full_unstemmed Peroxisome Proliferator-Activated Receptors Protect against Apoptosis via 14-3-3
title_sort peroxisome proliferator-activated receptors protect against apoptosis via 14-3-3
publisher Hindawi Limited
series PPAR Research
issn 1687-4757
1687-4765
publishDate 2010-01-01
description Peroxisome proliferator-activated receptors (PPARs) were reported to prevent cells from stress-induced apoptosis and protect tissues against ischemia-reperfusion injury. The underlying transcriptional mechanism is unclear. Recent reports indicate that the antiapoptotic actions of ligand-activated PPARδ and PPARγ are mediated through enhanced binding of PPAR to the promoter of 14-3-3ε and upregulation of 14-3-3ε expression. We propose that ligand-activated PPARα exerts its anti-apoptotic actions via the identical pathway. The PPAR to 14-3-3 transcriptional axis plays an important role in protection of cell and tissue integrity and is a target for drug discovery.
url http://dx.doi.org/10.1155/2010/417646
work_keys_str_mv AT kennethkwu peroxisomeproliferatoractivatedreceptorsprotectagainstapoptosisvia1433
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