Very ‘sticky’ proteins – not too sticky after all?
<p>Abstract</p> <p>A considerable number of soluble proteins in cells that biochemists try to analyze are difficult to handle because they seem to behave like sponges that ‘suck up’ many other proteins. We argue here that this behavior is commonly an artifact introduced by the expe...
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| Format: | Article |
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BMC
2012-06-01
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| Series: | Cell Communication and Signaling |
| Online Access: | http://www.biosignaling.com/content/10/1/15 |
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doaj-09d9784a20e846518995763084b4b4a62020-11-25T00:38:08ZengBMCCell Communication and Signaling1478-811X2012-06-011011510.1186/1478-811X-10-15Very ‘sticky’ proteins – not too sticky after all?Feller Stephan MLewitzky Marc<p>Abstract</p> <p>A considerable number of soluble proteins in cells that biochemists try to analyze are difficult to handle because they seem to behave like sponges that ‘suck up’ many other proteins. We argue here that this behavior is commonly an artifact introduced by the experimenting scientist and that we need to study proteins like animals in the wild: they will only reveal many of their secrets when carefully observed in their largely undisturbed, natural environment. Computational studies that attempt to realistically model cellular protein networks must also factor in the diverse protein habitats to be found in cells.</p> http://www.biosignaling.com/content/10/1/15 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Feller Stephan M Lewitzky Marc |
| spellingShingle |
Feller Stephan M Lewitzky Marc Very ‘sticky’ proteins – not too sticky after all? Cell Communication and Signaling |
| author_facet |
Feller Stephan M Lewitzky Marc |
| author_sort |
Feller Stephan M |
| title |
Very ‘sticky’ proteins – not too sticky after all? |
| title_short |
Very ‘sticky’ proteins – not too sticky after all? |
| title_full |
Very ‘sticky’ proteins – not too sticky after all? |
| title_fullStr |
Very ‘sticky’ proteins – not too sticky after all? |
| title_full_unstemmed |
Very ‘sticky’ proteins – not too sticky after all? |
| title_sort |
very ‘sticky’ proteins – not too sticky after all? |
| publisher |
BMC |
| series |
Cell Communication and Signaling |
| issn |
1478-811X |
| publishDate |
2012-06-01 |
| description |
<p>Abstract</p> <p>A considerable number of soluble proteins in cells that biochemists try to analyze are difficult to handle because they seem to behave like sponges that ‘suck up’ many other proteins. We argue here that this behavior is commonly an artifact introduced by the experimenting scientist and that we need to study proteins like animals in the wild: they will only reveal many of their secrets when carefully observed in their largely undisturbed, natural environment. Computational studies that attempt to realistically model cellular protein networks must also factor in the diverse protein habitats to be found in cells.</p> |
| url |
http://www.biosignaling.com/content/10/1/15 |
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