The antimicrobial activity and toxicity od alkyltetrahydroisoquinolones

The antibacterial and antifungal activity against gram-positive and gram-negative bacteria and Candida albicans fungal strain for alkyltetrahydroisoquinoline derivatives were evaluated. It was established, that 1,11-bis(6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)undecan shows pronounced antiba...

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Main Authors:	E. Terenteva, S. Sasmakov, S. Azimov, V. Vinogradova, D. Abdurakhmanov, Z. Khashimova, A. Saidov
Format:	Article
Language:	English
Published:	Taras Shevchenko National University of Kyiv 2018-03-01
Series:	Vìsnik: Kiïvsʹkij Nacìonalʹnij Unìversitet Imenì Tarasa Ševčenka. Bìologìâ
Subjects:	alkyltetrahydroisoquinolines, IC50, LD50, the antimicrobial activity, toxicity.
Online Access:	http://biovestnik.com/index.php/biology/article/view/291

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spelling	doaj-09cb4bb535e848d3b7a6ab6ed8d0db662020-11-25T00:26:51ZengTaras Shevchenko National University of KyivVìsnik: Kiïvsʹkij Nacìonalʹnij Unìversitet Imenì Tarasa Ševčenka. Bìologìâ1728-27482308-80362018-03-01742515510.17721/1728_2748.2017.74.51-55198The antimicrobial activity and toxicity od alkyltetrahydroisoquinolonesE. Terenteva0S. Sasmakov1S. Azimov2V. Vinogradova3D. Abdurakhmanov4Z. Khashimova5A. Saidov6Institute of the Chemistry of Plant Substances, Uzbek Academy of Sciences, TashkentInstitute of the Chemistry of Plant Substances, Uzbek Academy of Sciences, TashkentInstitute of the Chemistry of Plant Substances, Uzbek Academy of Sciences, TashkentInstitute of the Chemistry of Plant Substances, Uzbek Academy of SciencesInstitute of the Chemistry of Plant Substances, Uzbek Academy of SciencesInstitute of the Bioorganic Chemistry, Uzbek Academy of Sciences,TashkentSamarkand State University, SamarkandThe antibacterial and antifungal activity against gram-positive and gram-negative bacteria and Candida albicans fungal strain for alkyltetrahydroisoquinoline derivatives were evaluated. It was established, that 1,11-bis(6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)undecan shows pronounced antibacterial properties against all the microorganism strains and strong antifungal activity against Candida albicans with greater inhibition area than the reference drug. IC50 value of the compound is 2,1±0,1 μg/ml, LD50 value is 324,9±18,2 mg/kg.http://biovestnik.com/index.php/biology/article/view/291alkyltetrahydroisoquinolines, IC50, LD50, the antimicrobial activity, toxicity.
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	E. Terenteva S. Sasmakov S. Azimov V. Vinogradova D. Abdurakhmanov Z. Khashimova A. Saidov
spellingShingle	E. Terenteva S. Sasmakov S. Azimov V. Vinogradova D. Abdurakhmanov Z. Khashimova A. Saidov The antimicrobial activity and toxicity od alkyltetrahydroisoquinolones Vìsnik: Kiïvsʹkij Nacìonalʹnij Unìversitet Imenì Tarasa Ševčenka. Bìologìâ alkyltetrahydroisoquinolines, IC50, LD50, the antimicrobial activity, toxicity.
author_facet	E. Terenteva S. Sasmakov S. Azimov V. Vinogradova D. Abdurakhmanov Z. Khashimova A. Saidov
author_sort	E. Terenteva
title	The antimicrobial activity and toxicity od alkyltetrahydroisoquinolones
title_short	The antimicrobial activity and toxicity od alkyltetrahydroisoquinolones
title_full	The antimicrobial activity and toxicity od alkyltetrahydroisoquinolones
title_fullStr	The antimicrobial activity and toxicity od alkyltetrahydroisoquinolones
title_full_unstemmed	The antimicrobial activity and toxicity od alkyltetrahydroisoquinolones
title_sort	antimicrobial activity and toxicity od alkyltetrahydroisoquinolones
publisher	Taras Shevchenko National University of Kyiv
series	Vìsnik: Kiïvsʹkij Nacìonalʹnij Unìversitet Imenì Tarasa Ševčenka. Bìologìâ
issn	1728-2748 2308-8036
publishDate	2018-03-01
description	The antibacterial and antifungal activity against gram-positive and gram-negative bacteria and Candida albicans fungal strain for alkyltetrahydroisoquinoline derivatives were evaluated. It was established, that 1,11-bis(6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)undecan shows pronounced antibacterial properties against all the microorganism strains and strong antifungal activity against Candida albicans with greater inhibition area than the reference drug. IC50 value of the compound is 2,1±0,1 μg/ml, LD50 value is 324,9±18,2 mg/kg.
topic	alkyltetrahydroisoquinolines, IC50, LD50, the antimicrobial activity, toxicity.
url	http://biovestnik.com/index.php/biology/article/view/291
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The antimicrobial activity and toxicity od alkyltetrahydroisoquinolones

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