Nanoparticles containing constrained phospholipids deliver mRNA to liver immune cells in vivo without targeting ligands

Nanoparticles containing constrained phospholipids deliver mRNA to liver immune cells in vivo without targeting ligands

Abstract Once inside the cytoplasm of a cell, mRNA can be used to treat disease by upregulating the expression of any gene. Lipid nanoparticles (LNPs) can deliver mRNA to hepatocytes in humans, yet systemic non‐hepatocyte delivery at clinical doses remains difficult. We noted that LNPs have historic...

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Bibliographic Details
Main Authors: Zubao Gan, Melissa P. Lokugamage, Marine Z. C. Hatit, David Loughrey, Kalina Paunovska, Manaka Sato, Ana Cristian, James E. Dahlman
Format: Article
Language:English
Published: Wiley 2020-09-01
Series:Bioengineering & Translational Medicine
Subjects:
drug delivery
dna barcoding
gene therapies
LNP
mRNA
Online Access:https://doi.org/10.1002/btm2.10161

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