Novel Mechanisms for IGF-I Regulation by Glucagon in Carp Hepatocytes: Up-Regulation of HNF1α and CREB Expression via Signaling Crosstalk for IGF-I Gene Transcription

Novel Mechanisms for IGF-I Regulation by Glucagon in Carp Hepatocytes: Up-Regulation of HNF1α and CREB Expression via Signaling Crosstalk for IGF-I Gene Transcription

Glucagon, a key hormone for glucose homeostasis, can exert functional crosstalk with somatotropic axis via modification of IGF-I expression. However, its effect on IGF-I regulation is highly variable in different studies and the mechanisms involved are largely unknown. Using grass carp as a model, t...

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Bibliographic Details
Main Authors: Jin Bai, Xue Jiang, Mulan He, Ben C. B. Chan, Anderson O. L. Wong
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Endocrinology
Subjects:
IGF-I
glucagon
HNF1α
CREB
signal transduction
gene expression
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2019.00605/full

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