An efficient Hantzsch synthesis of 1,4-dihydropyridines using p-toluenesulfonic acid under solvent-free condition
An efficient Hantzsch synthesis of various substituted 1,4-dihydropyridines from an aldehyde, a β-dicarbonyl compound and ammonium acetate using p-toluenesulfonic acid in a solvent-free condition in the absence of any other co-catalyst is described. The process is simple...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Maejo University
2014-03-01
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| Series: | Maejo International Journal of Science and Technology |
| Subjects: | |
| Online Access: | http://www.mijst.mju.ac.th/vol8/32-40.pdf |
| Summary: | An efficient Hantzsch synthesis of various substituted 1,4-dihydropyridines from an
aldehyde, a β-dicarbonyl compound and ammonium acetate using p-toluenesulfonic acid in a
solvent-free condition in the absence of any other co-catalyst is described. The process is simple
and environmentally benign and the catalyst is commercially available and inexpensive. This
method has the advantages of excellent yield (80–96%) and short reaction time (5-20 min.).
Irradiation of a typical 1,4-dihydropyridine leads to the corresponding pyridine.
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| ISSN: | 1905-7873 1905-7873 |