ELAVL1 is transcriptionally activated by FOXC1 and promotes ferroptosis in myocardial ischemia/reperfusion injury by regulating autophagy

ELAVL1 is transcriptionally activated by FOXC1 and promotes ferroptosis in myocardial ischemia/reperfusion injury by regulating autophagy

Abstract Aims Myocardial ischemia is the most common form of cardiovascular disease and the leading cause of morbidity and mortality. Understanding the mechanisms is very crucial for the development of effective therapy. Therefore, this study aimed to investigate the functional roles and mechanisms...

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Bibliographic Details
Main Authors: Hui-Yong Chen, Ze-Zhou Xiao, Xiao Ling, Rong-Ning Xu, Peng Zhu, Shao-Yi Zheng
Format: Article
Language:English
Published: BMC 2021-02-01
Series:Molecular Medicine
Subjects:
Myocardial ischemia reperfusion
Ferroptosis
Autophagy
ELAVL1
FOXC1
Online Access:https://doi.org/10.1186/s10020-021-00271-w

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