Vitamin B6 deficiency disrupts serotonin signaling in pancreatic islets and induces gestational diabetes in mice

Vitamin B6 deficiency disrupts serotonin signaling in pancreatic islets and induces gestational diabetes in mice

Fields et al. investigate the impact of vitamin B6 deficiency on islet β-cell proliferation during pregnancy, using vitamin B6-deficient mice. They find that gestational vitamin B6 deficiency decreases serotonin levels in pancreatic islets and reduces β-cell proliferation, showing that vitamin B6 de...

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Main Authors: Ashley M. Fields, Kevin Welle, Elaine S. Ho, Clementina Mesaros, Martha Susiarjo
Format: Article
Language:English
Published: Nature Publishing Group 2021-03-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-021-01900-0
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spelling doaj-09af5f83b4974b0d925a99ec862ef5812021-03-28T11:24:08ZengNature Publishing GroupCommunications Biology2399-36422021-03-014111010.1038/s42003-021-01900-0Vitamin B6 deficiency disrupts serotonin signaling in pancreatic islets and induces gestational diabetes in miceAshley M. Fields0Kevin Welle1Elaine S. Ho2Clementina Mesaros3Martha Susiarjo4Department of Environmental Medicine, University of Rochester School of Medicine and DentistryMass Spectrometry Resource Laboratory, University of RochesterDepartment of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School of MedicineDepartment of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School of MedicineDepartment of Environmental Medicine, University of Rochester School of Medicine and DentistryFields et al. investigate the impact of vitamin B6 deficiency on islet β-cell proliferation during pregnancy, using vitamin B6-deficient mice. They find that gestational vitamin B6 deficiency decreases serotonin levels in pancreatic islets and reduces β-cell proliferation, showing that vitamin B6 deficiency regulates maternal glucose tolerance in a serotonin-dependent manner.https://doi.org/10.1038/s42003-021-01900-0
collection DOAJ
language English
format Article
sources DOAJ
author Ashley M. Fields
Kevin Welle
Elaine S. Ho
Clementina Mesaros
Martha Susiarjo
spellingShingle Ashley M. Fields
Kevin Welle
Elaine S. Ho
Clementina Mesaros
Martha Susiarjo
Vitamin B6 deficiency disrupts serotonin signaling in pancreatic islets and induces gestational diabetes in mice
Communications Biology
author_facet Ashley M. Fields
Kevin Welle
Elaine S. Ho
Clementina Mesaros
Martha Susiarjo
author_sort Ashley M. Fields
title Vitamin B6 deficiency disrupts serotonin signaling in pancreatic islets and induces gestational diabetes in mice
title_short Vitamin B6 deficiency disrupts serotonin signaling in pancreatic islets and induces gestational diabetes in mice
title_full Vitamin B6 deficiency disrupts serotonin signaling in pancreatic islets and induces gestational diabetes in mice
title_fullStr Vitamin B6 deficiency disrupts serotonin signaling in pancreatic islets and induces gestational diabetes in mice
title_full_unstemmed Vitamin B6 deficiency disrupts serotonin signaling in pancreatic islets and induces gestational diabetes in mice
title_sort vitamin b6 deficiency disrupts serotonin signaling in pancreatic islets and induces gestational diabetes in mice
publisher Nature Publishing Group
series Communications Biology
issn 2399-3642
publishDate 2021-03-01
description Fields et al. investigate the impact of vitamin B6 deficiency on islet β-cell proliferation during pregnancy, using vitamin B6-deficient mice. They find that gestational vitamin B6 deficiency decreases serotonin levels in pancreatic islets and reduces β-cell proliferation, showing that vitamin B6 deficiency regulates maternal glucose tolerance in a serotonin-dependent manner.
url https://doi.org/10.1038/s42003-021-01900-0
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AT clementinamesaros vitaminb6deficiencydisruptsserotoninsignalinginpancreaticisletsandinducesgestationaldiabetesinmice
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