Value of serum pepsinogen Ⅰ and Ⅱ ratio for evaluating the malignant biological behaviors in gastric cancer lesions
Objective: To study the value of serum pepsinogen Ⅰ and Ⅱ ratio (PGR) for evaluating the malignant biological behaviors in gastric cancer lesions. Methods: The patients with gastric cancer who underwent radical surgery in 363 Hospital between July 2015 and February 2018 were selected as the gastr...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Editorial Board of Journal of Hainan Medical University
2018-10-01
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| Series: | Journal of Hainan Medical University |
| Subjects: | |
| Online Access: | http://www.hnykdxxb.com/PDF/201820/15.pdf |
| Summary: | Objective: To study the value of serum pepsinogen Ⅰ and Ⅱ ratio (PGR) for evaluating the
malignant biological behaviors in gastric cancer lesions. Methods: The patients with gastric
cancer who underwent radical surgery in 363 Hospital between July 2015 and February 2018
were selected as the gastric cancer group in the study, and the volunteers who had physical
examination in 363 Hospital during the same period were selected as the control group. Serum
was collected to measure pepsinogen Ⅰ and pepsinogen Ⅱ and then calculate the PGR;
gastric cancer lesions were collected to measure the expression of oncogenes and angiogenesis
genes. Results: Serum PGR level of the gastric cancer group was significantly lower than that
of the control group, serum PGR level of the patients with moderately-highly differentiated
gastric cancer was significantly higher than that of the patients with lowly differentiated gastric
cancer, serum PGR level of the patients with TNM stage III gastric cancer was significantly
lower than that of the patients with TNM stage I+II gastric cancer, and serum PGR level of
the gastric cancer patients with lymph node metastasis was significantly lower than that of the
gastric cancer patients without lymph node metastasis; PGR=3.8 was taken as the cutoff point,
and p53 and TXNIP mRNA expression in the lesions of the gastric cancer patients with PGR
< 3.8 were significantly lower than those of the gastric cancer patients with PGR > 3.8 while
Bcl-2, β-catenin, Survivin, COX-2, HIF-1毩, VEGF, c-Met and CNPY2 mRNA expression
were significantly higher than those of the gastric cancer patients with PGR > 3.8. Conclusion:
The decrease of PGR in serum of patients with gastric cancer is valuable for evaluating the
pathological process and malignant biological behaviors. |
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| ISSN: | 1007-1237 1007-1237 |