Numerical Study of Bloodstream Diffusion of the New Generation of Drug-Eluting Stents in Coronary Arteries

Numerical Study of Bloodstream Diffusion of the New Generation of Drug-Eluting Stents in Coronary Arteries

The present work aims at developing a numerical study on the drug diffusion in the bloodstream in a coronary artery with drug-eluting stent implanted. The blood was modeled as a single-phase, incompressible and Newtonian fluid and the Navier–Stokes equation was approximated according to the Finite E...

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Main Authors: Leandro Marques, Gustavo R. Anjos
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Fluids
Subjects:
angioplasty
cardiovascular disease
drug-eluting stent
real artery geometry
microchannels
finite element method
Online Access:https://www.mdpi.com/2311-5521/6/2/71
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spelling doaj-09ab3bf758f84875b4c17985ee84ea162021-02-06T00:03:21ZengMDPI AGFluids2311-55212021-02-016717110.3390/fluids6020071Numerical Study of Bloodstream Diffusion of the New Generation of Drug-Eluting Stents in Coronary ArteriesLeandro Marques0Gustavo R. Anjos1Graduate Program in Mechanical Engineering, GESAR/Department of Mechanical Engineering, Rio de Janeiro State University, Rio de Janeiro, RJ 20943-000, BrazilCOPPE/Department of Mechanical Engineering, Federal University of Rio de Janeiro, Ilha do Fundão, Rio de Janeiro, RJ 21941-914, BrazilThe present work aims at developing a numerical study on the drug diffusion in the bloodstream in a coronary artery with drug-eluting stent implanted. The blood was modeled as a single-phase, incompressible and Newtonian fluid and the Navier–Stokes equation was approximated according to the Finite Element Method (FEM). The dynamics of drug-eluting concentration in bloodstream was investigated using four drug-eluting stents with different mass diffusivities in microchannels with variable cross sections, including a real coronary artery geometry with atherosclerosis. The results reveal complex drug concentration patterns and accumulation in the vicinity of the fat buildup.https://www.mdpi.com/2311-5521/6/2/71angioplastycardiovascular diseasedrug-eluting stentreal artery geometrymicrochannelsfinite element method
collection DOAJ
language English
format Article
sources DOAJ
author Leandro Marques
Gustavo R. Anjos
spellingShingle Leandro Marques
Gustavo R. Anjos
Numerical Study of Bloodstream Diffusion of the New Generation of Drug-Eluting Stents in Coronary Arteries
Fluids
angioplasty
cardiovascular disease
drug-eluting stent
real artery geometry
microchannels
finite element method
author_facet Leandro Marques
Gustavo R. Anjos
author_sort Leandro Marques
title Numerical Study of Bloodstream Diffusion of the New Generation of Drug-Eluting Stents in Coronary Arteries
title_short Numerical Study of Bloodstream Diffusion of the New Generation of Drug-Eluting Stents in Coronary Arteries
title_full Numerical Study of Bloodstream Diffusion of the New Generation of Drug-Eluting Stents in Coronary Arteries
title_fullStr Numerical Study of Bloodstream Diffusion of the New Generation of Drug-Eluting Stents in Coronary Arteries
title_full_unstemmed Numerical Study of Bloodstream Diffusion of the New Generation of Drug-Eluting Stents in Coronary Arteries
title_sort numerical study of bloodstream diffusion of the new generation of drug-eluting stents in coronary arteries
publisher MDPI AG
series Fluids
issn 2311-5521
publishDate 2021-02-01
description The present work aims at developing a numerical study on the drug diffusion in the bloodstream in a coronary artery with drug-eluting stent implanted. The blood was modeled as a single-phase, incompressible and Newtonian fluid and the Navier–Stokes equation was approximated according to the Finite Element Method (FEM). The dynamics of drug-eluting concentration in bloodstream was investigated using four drug-eluting stents with different mass diffusivities in microchannels with variable cross sections, including a real coronary artery geometry with atherosclerosis. The results reveal complex drug concentration patterns and accumulation in the vicinity of the fat buildup.
topic angioplasty
cardiovascular disease
drug-eluting stent
real artery geometry
microchannels
finite element method
url https://www.mdpi.com/2311-5521/6/2/71
work_keys_str_mv AT leandromarques numericalstudyofbloodstreamdiffusionofthenewgenerationofdrugelutingstentsincoronaryarteries
AT gustavoranjos numericalstudyofbloodstreamdiffusionofthenewgenerationofdrugelutingstentsincoronaryarteries
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