Numerical Study of Bloodstream Diffusion of the New Generation of Drug-Eluting Stents in Coronary Arteries

Numerical Study of Bloodstream Diffusion of the New Generation of Drug-Eluting Stents in Coronary Arteries

The present work aims at developing a numerical study on the drug diffusion in the bloodstream in a coronary artery with drug-eluting stent implanted. The blood was modeled as a single-phase, incompressible and Newtonian fluid and the Navier–Stokes equation was approximated according to the Finite E...

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Bibliographic Details
Main Authors: Leandro Marques, Gustavo R. Anjos
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Fluids
Subjects:
angioplasty
cardiovascular disease
drug-eluting stent
real artery geometry
microchannels
finite element method
Online Access:https://www.mdpi.com/2311-5521/6/2/71
Description
Summary:The present work aims at developing a numerical study on the drug diffusion in the bloodstream in a coronary artery with drug-eluting stent implanted. The blood was modeled as a single-phase, incompressible and Newtonian fluid and the Navier–Stokes equation was approximated according to the Finite Element Method (FEM). The dynamics of drug-eluting concentration in bloodstream was investigated using four drug-eluting stents with different mass diffusivities in microchannels with variable cross sections, including a real coronary artery geometry with atherosclerosis. The results reveal complex drug concentration patterns and accumulation in the vicinity of the fat buildup.
ISSN:2311-5521

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