Retinal waves are unlikely to instruct the formation of eye-specific retinogeniculate projections

<p>Abstract</p> <p>In all mammalian species the projections of the two eyes to the dorsal lateral geniculate nucleus are initially overlapping before gradually forming the eye-specific domains evident at maturity. It is widely thought that retinal waves of neuronal activity play an...

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Main Author:	Chalupa Leo M
Format:	Article
Language:	English
Published:	BMC 2009-07-01
Series:	Neural Development
Online Access:	http://www.neuraldevelopment.com/content/4/1/25

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spelling	doaj-09a87862624b4462966ff71221e2c96b2020-11-24T21:44:41ZengBMCNeural Development1749-81042009-07-01412510.1186/1749-8104-4-25Retinal waves are unlikely to instruct the formation of eye-specific retinogeniculate projectionsChalupa Leo M<p>Abstract</p> <p>In all mammalian species the projections of the two eyes to the dorsal lateral geniculate nucleus are initially overlapping before gradually forming the eye-specific domains evident at maturity. It is widely thought that retinal waves of neuronal activity play an instructional role in this developmental process. Here, I discuss the myriad reasons why retinal waves are unlikely to have such a role, and suggest that eye-specific molecular cues in combination with neuronal activity are most probably involved in the formation of eye-specific retinogeniculate projections.</p> http://www.neuraldevelopment.com/content/4/1/25
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Chalupa Leo M
spellingShingle	Chalupa Leo M Retinal waves are unlikely to instruct the formation of eye-specific retinogeniculate projections Neural Development
author_facet	Chalupa Leo M
author_sort	Chalupa Leo M
title	Retinal waves are unlikely to instruct the formation of eye-specific retinogeniculate projections
title_short	Retinal waves are unlikely to instruct the formation of eye-specific retinogeniculate projections
title_full	Retinal waves are unlikely to instruct the formation of eye-specific retinogeniculate projections
title_fullStr	Retinal waves are unlikely to instruct the formation of eye-specific retinogeniculate projections
title_full_unstemmed	Retinal waves are unlikely to instruct the formation of eye-specific retinogeniculate projections
title_sort	retinal waves are unlikely to instruct the formation of eye-specific retinogeniculate projections
publisher	BMC
series	Neural Development
issn	1749-8104
publishDate	2009-07-01
description	<p>Abstract</p> <p>In all mammalian species the projections of the two eyes to the dorsal lateral geniculate nucleus are initially overlapping before gradually forming the eye-specific domains evident at maturity. It is widely thought that retinal waves of neuronal activity play an instructional role in this developmental process. Here, I discuss the myriad reasons why retinal waves are unlikely to have such a role, and suggest that eye-specific molecular cues in combination with neuronal activity are most probably involved in the formation of eye-specific retinogeniculate projections.</p>
url	http://www.neuraldevelopment.com/content/4/1/25
work_keys_str_mv	AT chalupaleom retinalwavesareunlikelytoinstructtheformationofeyespecificretinogeniculateprojections
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Retinal waves are unlikely to instruct the formation of eye-specific retinogeniculate projections

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