Retinal waves are unlikely to instruct the formation of eye-specific retinogeniculate projections
<p>Abstract</p> <p>In all mammalian species the projections of the two eyes to the dorsal lateral geniculate nucleus are initially overlapping before gradually forming the eye-specific domains evident at maturity. It is widely thought that retinal waves of neuronal activity play an...
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| Format: | Article |
| Language: | English |
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BMC
2009-07-01
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| Series: | Neural Development |
| Online Access: | http://www.neuraldevelopment.com/content/4/1/25 |
| Summary: | <p>Abstract</p> <p>In all mammalian species the projections of the two eyes to the dorsal lateral geniculate nucleus are initially overlapping before gradually forming the eye-specific domains evident at maturity. It is widely thought that retinal waves of neuronal activity play an instructional role in this developmental process. Here, I discuss the myriad reasons why retinal waves are unlikely to have such a role, and suggest that eye-specific molecular cues in combination with neuronal activity are most probably involved in the formation of eye-specific retinogeniculate projections.</p> |
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| ISSN: | 1749-8104 |