Notch1 signaling pathway promotes invasion, self-renewal and growth of glioma initiating cells via modulating chemokine system CXCL12/CXCR4

Notch1 signaling pathway promotes invasion, self-renewal and growth of glioma initiating cells via modulating chemokine system CXCL12/CXCR4

Abstract Background Glioma initiating cells (GICs), also known as glioma stem cells (GSCs), play an important role in the progression and recurrence of glioblastoma multiforme (GBM) due to their potential for self-renewal, multiple differentiation and tumor initiation. In the recent years, Notch1 ha...

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Bibliographic Details
Main Authors: Li Yi, Xingchen Zhou, Tao Li, Peidong Liu, Long Hai, Luqing Tong, Haiwen Ma, Zhennan Tao, Yang Xie, Chen Zhang, Shengping Yu, Xuejun Yang
Format: Article
Language:English
Published: BMC 2019-08-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Glioma initiating cells
Notch1
CXCR4
Invasion
Migration
Online Access:http://link.springer.com/article/10.1186/s13046-019-1319-4

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