Molecular Mechanisms of MYCN Dysregulation in Cancers

MYCN, a member of MYC proto-oncogene family, encodes a basic helix-loop-helix transcription factor N-MYC. Abnormal expression of N-MYC is correlated with high-risk cancers and poor prognosis. Initially identified as an amplified oncogene in neuroblastoma in 1983, the oncogenic effect of N-MYC is exp...

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Main Authors:	Ruochen Liu, Pengfei Shi, Zhongze Wang, Chaoyu Yuan, Hongjuan Cui
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-02-01
Series:	Frontiers in Oncology
Subjects:	MYCN cancer gene amplification G-quadruplex NCYM super enhancer
Online Access:	https://www.frontiersin.org/articles/10.3389/fonc.2020.625332/full

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spelling	doaj-09a14b103bad46c1926281b7b01d89492021-02-03T05:30:05ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2021-02-011010.3389/fonc.2020.625332625332Molecular Mechanisms of MYCN Dysregulation in CancersRuochen Liu0Ruochen Liu1Ruochen Liu2Pengfei Shi3Pengfei Shi4Pengfei Shi5Zhongze Wang6Zhongze Wang7Chaoyu Yuan8Chaoyu Yuan9Hongjuan Cui10Hongjuan Cui11Hongjuan Cui12State Key Laboratory of Silkworm Genome Biology, College of Sericulture, Textile and Biomass Sciences, Southwest University, Chongqing, ChinaCancer Center, Reproductive Medicine Center, Medical Research Institute, Southwest University, Chongqing, ChinaNHC Key Laboratory of Birth Defects and Reproductive Health (Chongqing Key Laboratory of Birth Defects and Reproductive Health, Chongqing Population and Family Planning Science and Technology Research Institute), Chongqing, ChinaState Key Laboratory of Silkworm Genome Biology, College of Sericulture, Textile and Biomass Sciences, Southwest University, Chongqing, ChinaCancer Center, Reproductive Medicine Center, Medical Research Institute, Southwest University, Chongqing, ChinaNHC Key Laboratory of Birth Defects and Reproductive Health (Chongqing Key Laboratory of Birth Defects and Reproductive Health, Chongqing Population and Family Planning Science and Technology Research Institute), Chongqing, ChinaState Key Laboratory of Silkworm Genome Biology, College of Sericulture, Textile and Biomass Sciences, Southwest University, Chongqing, ChinaCancer Center, Reproductive Medicine Center, Medical Research Institute, Southwest University, Chongqing, ChinaState Key Laboratory of Silkworm Genome Biology, College of Sericulture, Textile and Biomass Sciences, Southwest University, Chongqing, ChinaCancer Center, Reproductive Medicine Center, Medical Research Institute, Southwest University, Chongqing, ChinaState Key Laboratory of Silkworm Genome Biology, College of Sericulture, Textile and Biomass Sciences, Southwest University, Chongqing, ChinaCancer Center, Reproductive Medicine Center, Medical Research Institute, Southwest University, Chongqing, ChinaNHC Key Laboratory of Birth Defects and Reproductive Health (Chongqing Key Laboratory of Birth Defects and Reproductive Health, Chongqing Population and Family Planning Science and Technology Research Institute), Chongqing, ChinaMYCN, a member of MYC proto-oncogene family, encodes a basic helix-loop-helix transcription factor N-MYC. Abnormal expression of N-MYC is correlated with high-risk cancers and poor prognosis. Initially identified as an amplified oncogene in neuroblastoma in 1983, the oncogenic effect of N-MYC is expanded to multiple neuronal and nonneuronal tumors. Direct targeting N-MYC remains challenge due to its “undruggable” features. Therefore, alternative therapeutic approaches for targeting MYCN-driven tumors have been focused on the disruption of transcription, translation, protein stability as well as synthetic lethality of MYCN. In this review, we summarize the latest advances in understanding the molecular mechanisms of MYCN dysregulation in cancers.https://www.frontiersin.org/articles/10.3389/fonc.2020.625332/fullMYCNcancergene amplificationG-quadruplexNCYMsuper enhancer
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Ruochen Liu Ruochen Liu Ruochen Liu Pengfei Shi Pengfei Shi Pengfei Shi Zhongze Wang Zhongze Wang Chaoyu Yuan Chaoyu Yuan Hongjuan Cui Hongjuan Cui Hongjuan Cui
spellingShingle	Ruochen Liu Ruochen Liu Ruochen Liu Pengfei Shi Pengfei Shi Pengfei Shi Zhongze Wang Zhongze Wang Chaoyu Yuan Chaoyu Yuan Hongjuan Cui Hongjuan Cui Hongjuan Cui Molecular Mechanisms of MYCN Dysregulation in Cancers Frontiers in Oncology MYCN cancer gene amplification G-quadruplex NCYM super enhancer
author_facet	Ruochen Liu Ruochen Liu Ruochen Liu Pengfei Shi Pengfei Shi Pengfei Shi Zhongze Wang Zhongze Wang Chaoyu Yuan Chaoyu Yuan Hongjuan Cui Hongjuan Cui Hongjuan Cui
author_sort	Ruochen Liu
title	Molecular Mechanisms of MYCN Dysregulation in Cancers
title_short	Molecular Mechanisms of MYCN Dysregulation in Cancers
title_full	Molecular Mechanisms of MYCN Dysregulation in Cancers
title_fullStr	Molecular Mechanisms of MYCN Dysregulation in Cancers
title_full_unstemmed	Molecular Mechanisms of MYCN Dysregulation in Cancers
title_sort	molecular mechanisms of mycn dysregulation in cancers
publisher	Frontiers Media S.A.
series	Frontiers in Oncology
issn	2234-943X
publishDate	2021-02-01
description	MYCN, a member of MYC proto-oncogene family, encodes a basic helix-loop-helix transcription factor N-MYC. Abnormal expression of N-MYC is correlated with high-risk cancers and poor prognosis. Initially identified as an amplified oncogene in neuroblastoma in 1983, the oncogenic effect of N-MYC is expanded to multiple neuronal and nonneuronal tumors. Direct targeting N-MYC remains challenge due to its “undruggable” features. Therefore, alternative therapeutic approaches for targeting MYCN-driven tumors have been focused on the disruption of transcription, translation, protein stability as well as synthetic lethality of MYCN. In this review, we summarize the latest advances in understanding the molecular mechanisms of MYCN dysregulation in cancers.
topic	MYCN cancer gene amplification G-quadruplex NCYM super enhancer
url	https://www.frontiersin.org/articles/10.3389/fonc.2020.625332/full
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Molecular Mechanisms of MYCN Dysregulation in Cancers

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