Current Status of Translational Research on Constipation

• Main Authors: Hyun Jik Lee, Kyung Sik Park
• Format: Article
• Language: English
• Published: Jin Publishing & Printing Co. 2016-09-01
• Series: The Korean Journal of Gastroenterology
• Subjects: Constipation; Translational medical research; Gastrointestinal motility; Colon
• Online Access: http://www.kjg.or.kr/journal/view.html?doi=10.4166/kjg.2016.68.3.143

Constipation is one of the most common gastrointestinal disorders with a prevalence up to 16.5% in the general population. It is frequently multifactorial and the pathophysiologic mechanism of constipation is not fully understood. Many preclinical studies of constipation have used animal models. Translational research using these animal models is essential to the investigation of neurogenic and myogenic mechanisms of colon, and to the estimation of the clinical efficacy of new drugs. In this review, we discuss some of the current translational research projects on constipation using animal models. (Korean J Gastroenterol 2016;68:143-147)