Multiple gene variations contributed to congenital heart disease via GATA family transcriptional regulation

Multiple gene variations contributed to congenital heart disease via GATA family transcriptional regulation

Abstract Background Congenital heart disease (CHD) is a common birth defect, and most cases occur sporadically. Mutations in key genes that are responsible for cardiac development could contribute to CHD. To date, the genetic causes of CHD remain largely unknown. Methods In this study, twenty-nine c...

Full description

Bibliographic Details
Main Authors: Yanyan Qian, Deyong Xiao, Xiao Guo, Hongbo Chen, Lili Hao, Xiaojing Ma, Guoying Huang, Duan Ma, Huijun Wang
Format: Article
Language:English
Published: BMC 2017-04-01
Series:Journal of Translational Medicine
Subjects:
Congenital heart disease (CHD)
Next-generation sequencing
Functional study
Multigene disease
Variants
Online Access:http://link.springer.com/article/10.1186/s12967-017-1173-0

Internet

http://link.springer.com/article/10.1186/s12967-017-1173-0

Similar Items