Thioguanine-based DENV-2 NS2B/NS3 protease inhibitors: Virtual screening, synthesis, biological evaluation and molecular modelling.

Thioguanine-based DENV-2 NS2B/NS3 protease inhibitors: Virtual screening, synthesis, biological evaluation and molecular modelling.

Dengue virus Type 2 (DENV-2) is predominant serotype causing major dengue epidemics. There are a number of studies carried out to find its effective antiviral, however to date, there is still no molecule either from peptide or small molecules released as a drug. The present study aims to identify sm...

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Bibliographic Details
Main Authors: Maywan Hariono, Sy Bing Choi, Ros Fatihah Roslim, Mohamed Sufian Nawi, Mei Lan Tan, Ezatul Ezleen Kamarulzaman, Nornisah Mohamed, Rohana Yusof, Shatrah Othman, Noorsaadah Abd Rahman, Rozana Othman, Habibah A Wahab
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0210869

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