Kadar Lipid Darah Mencit Betina Middle-Aged Galur Swiss Webster setelah Pemberian Jus Buah Pare (Momordica charantia L.)

• Main Authors: Rita Shintawati, Hernawati, Desi Indraswati
• Format: Article
• Language: English
• Published: Universitas Padjajaran 2011-06-01
• Series: Majalah Kedokteran Bandung
• Subjects: Blood lipid; middle-aged female mice; pare fruit
• Online Access: http://journal.fk.unpad.ac.id/index.php/mkb/article/view/50
• ISSN: 0126-074X; 2338-6223

Ovarian aging has been noted in some vertebrate animals and human being, indicated by low estrogen level. This is related to enhancement of lipid (obesity) and some metabolic diseases such as hyperlipidemia, cardiovascular disease, etc. Pare juice (Momordica charantia L.), contains of abundant advantageous bioactivities, such as hypoglycemic effect, antioxidant, hypocholesterolemic, and hypotrigliseridemic. This research purposed was to determine blood lipid levels of mice at the age of middle-aged after being given pare juice. The experimental animal used 25 females mice of 10 months old (middle-aged) on March–April 2010 at Physiology Laboratory Universitas Pendidikan Indonesia and Veteriner Medicine IPB, divided into five different treatment groups (controle positive, controle negative, 0.5 mL/40 g bw, 1.0 mL/40 g bw, and 1.5 mL/40 g bw) which were fed with pare juice for 10 days. Completely randomized design was used in this research. Results showed that pare juice reduced lower body weight of mice (p<0.05) at all doses. Pare juice did not reduce total cholesterol levels, but increased HDL (p<0.05) at all doses. Other parameters to pare juice reduced triglyceride levels at doses of 1.5 mL/40 g BW (p<0.05) and LDL levels at dose 0.5 mL/40 g BW (136.49 mg/dL). In conclusions, pare juice can stabilize triglyseride and LDL cholesterol level at dose 0.5 mL/40 g BW and increases HDL cholesterol, but has no influence to total cholesterol.