Repurposing Chloroquine Against Multiple Diseases With Special Attention to SARS-CoV-2 and Associated Toxicity

Repurposing Chloroquine Against Multiple Diseases With Special Attention to SARS-CoV-2 and Associated Toxicity

Chloroquine and its derivatives have been used since ages to treat malaria and have also been approved by the FDA to treat autoimmune diseases. The drug employs pH-dependent inhibition of functioning and signalling of the endosome, lysosome and trans-Golgi network, immunomodulatory actions, inhibiti...

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Bibliographic Details
Main Authors: Siya Kamat, Madhuree Kumari
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Pharmacology
Subjects:
SARS-CoV-2
pH-dependent
autophagy
immunomodulatory
antiviral mechanism
toxicity
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.576093/full

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