Antimicrobial Peptides: A Potent Alternative to Antibiotics

Antimicrobial Peptides: A Potent Alternative to Antibiotics

Antimicrobial peptides constitute one of the most promising alternatives to antibiotics since they could be used to treat bacterial infections, especially those caused by multidrug-resistant pathogens. Many antimicrobial peptides, with various activity spectra and mechanisms of actions, have been de...

Full description

Bibliographic Details
Main Authors: Mariam Rima, Mohamad Rima, Ziad Fajloun, Jean-Marc Sabatier, Burkhard Bechinger, Thierry Naas
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Antibiotics
Subjects:
antimicrobial peptides
antibiotic resistance
multidrug resistance
ESKAPE
Online Access:https://www.mdpi.com/2079-6382/10/9/1095
id doaj-0976d454ef2a4fc599e603d14d03a027
record_format Article
spelling doaj-0976d454ef2a4fc599e603d14d03a0272021-09-25T23:37:25ZengMDPI AGAntibiotics2079-63822021-09-01101095109510.3390/antibiotics10091095Antimicrobial Peptides: A Potent Alternative to AntibioticsMariam Rima0Mohamad Rima1Ziad Fajloun2Jean-Marc Sabatier3Burkhard Bechinger4Thierry Naas5Team ReSIST, INSERM U1184, School of Medicine Université Paris-Saclay, 94270 Le Kremlin-Bicetre, FranceLaboratory of Applied Biotechnology, Azm Center for Research in Biotechnology and Its Applications, EDST, Lebanese University, Tripoli 1300, LebanonLaboratory of Applied Biotechnology, Azm Center for Research in Biotechnology and Its Applications, EDST, Lebanese University, Tripoli 1300, LebanonInstitut de Neuro Physiopathologie, UMR7051, Aix-Marseille Université, Faculté de Pharmacie, 27 Boulevard Jean Moulin, 13005 Marseille, FranceInstitut de Chimie de Strasbourg, CNRS, UMR7177, University of Strasbourg, 67008 Strasbourg, FranceTeam ReSIST, INSERM U1184, School of Medicine Université Paris-Saclay, 94270 Le Kremlin-Bicetre, FranceAntimicrobial peptides constitute one of the most promising alternatives to antibiotics since they could be used to treat bacterial infections, especially those caused by multidrug-resistant pathogens. Many antimicrobial peptides, with various activity spectra and mechanisms of actions, have been described. This review focuses on their use against ESKAPE bacteria, especially in biofilm treatments, their synergistic activity, and their application as prophylactic agents. Limitations and challenges restricting therapeutic applications are highlighted, and solutions for each challenge are evaluated to analyze whether antimicrobial peptides could replace antibiotics in the near future.https://www.mdpi.com/2079-6382/10/9/1095antimicrobial peptidesantibiotic resistancemultidrug resistanceESKAPE
collection DOAJ
language English
format Article
sources DOAJ
author Mariam Rima
Mohamad Rima
Ziad Fajloun
Jean-Marc Sabatier
Burkhard Bechinger
Thierry Naas
spellingShingle Mariam Rima
Mohamad Rima
Ziad Fajloun
Jean-Marc Sabatier
Burkhard Bechinger
Thierry Naas
Antimicrobial Peptides: A Potent Alternative to Antibiotics
Antibiotics
antimicrobial peptides
antibiotic resistance
multidrug resistance
ESKAPE
author_facet Mariam Rima
Mohamad Rima
Ziad Fajloun
Jean-Marc Sabatier
Burkhard Bechinger
Thierry Naas
author_sort Mariam Rima
title Antimicrobial Peptides: A Potent Alternative to Antibiotics
title_short Antimicrobial Peptides: A Potent Alternative to Antibiotics
title_full Antimicrobial Peptides: A Potent Alternative to Antibiotics
title_fullStr Antimicrobial Peptides: A Potent Alternative to Antibiotics
title_full_unstemmed Antimicrobial Peptides: A Potent Alternative to Antibiotics
title_sort antimicrobial peptides: a potent alternative to antibiotics
publisher MDPI AG
series Antibiotics
issn 2079-6382
publishDate 2021-09-01
description Antimicrobial peptides constitute one of the most promising alternatives to antibiotics since they could be used to treat bacterial infections, especially those caused by multidrug-resistant pathogens. Many antimicrobial peptides, with various activity spectra and mechanisms of actions, have been described. This review focuses on their use against ESKAPE bacteria, especially in biofilm treatments, their synergistic activity, and their application as prophylactic agents. Limitations and challenges restricting therapeutic applications are highlighted, and solutions for each challenge are evaluated to analyze whether antimicrobial peptides could replace antibiotics in the near future.
topic antimicrobial peptides
antibiotic resistance
multidrug resistance
ESKAPE
url https://www.mdpi.com/2079-6382/10/9/1095
work_keys_str_mv AT mariamrima antimicrobialpeptidesapotentalternativetoantibiotics
AT mohamadrima antimicrobialpeptidesapotentalternativetoantibiotics
AT ziadfajloun antimicrobialpeptidesapotentalternativetoantibiotics
AT jeanmarcsabatier antimicrobialpeptidesapotentalternativetoantibiotics
AT burkhardbechinger antimicrobialpeptidesapotentalternativetoantibiotics
AT thierrynaas antimicrobialpeptidesapotentalternativetoantibiotics
_version_ 1717368421356666880

Similar Items