Crosstalk signaling between alveoli and capillaries

Crosstalk signaling between alveoli and capillaries

Crosstalk signaling between the closely juxtaposed epithelial and endothelial membranes of pulmonary alveoli establishes the lung’s immune defense against inhaled and blood-borne pathogens. The crosstalk can occur in a forward direction, as from alveolus to capillary, or in a reverse direction, as f...

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Main Authors: Rebecca F. Hough, Sunita Bhattacharya, Jahar Bhattacharya
Format: Article
Language:English
Published: SAGE Publishing 2018-06-01
Series:Pulmonary Circulation
Online Access:https://doi.org/10.1177/2045894018783735
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spelling doaj-0975cac258884b47a132ddaf9d05c57e2020-11-25T02:46:57ZengSAGE PublishingPulmonary Circulation2045-89402018-06-01810.1177/2045894018783735Crosstalk signaling between alveoli and capillariesRebecca F. Hough0Sunita Bhattacharya1Jahar Bhattacharya2Department of Pediatrics, Columbia University College of Physicians & Surgeons, New York, NY, USADepartment of Pediatrics, Columbia University College of Physicians & Surgeons, New York, NY, USADepartment of Medicine, Columbia University College of Physicians & Surgeons, New York, NY, USACrosstalk signaling between the closely juxtaposed epithelial and endothelial membranes of pulmonary alveoli establishes the lung’s immune defense against inhaled and blood-borne pathogens. The crosstalk can occur in a forward direction, as from alveolus to capillary, or in a reverse direction, as from capillary to alveolus. The crosstalk direction likely depends on the site at which pathogens first initiate signaling. Thus, forward crosstalk may occur when inhaled pathogens encounter the alveolar epithelium, while reverse crosstalk may result from interactions of blood-borne pathogens with the endothelium. Here, we review the factors that regulate these two directions of signaling.https://doi.org/10.1177/2045894018783735
collection DOAJ
language English
format Article
sources DOAJ
author Rebecca F. Hough
Sunita Bhattacharya
Jahar Bhattacharya
spellingShingle Rebecca F. Hough
Sunita Bhattacharya
Jahar Bhattacharya
Crosstalk signaling between alveoli and capillaries
Pulmonary Circulation
author_facet Rebecca F. Hough
Sunita Bhattacharya
Jahar Bhattacharya
author_sort Rebecca F. Hough
title Crosstalk signaling between alveoli and capillaries
title_short Crosstalk signaling between alveoli and capillaries
title_full Crosstalk signaling between alveoli and capillaries
title_fullStr Crosstalk signaling between alveoli and capillaries
title_full_unstemmed Crosstalk signaling between alveoli and capillaries
title_sort crosstalk signaling between alveoli and capillaries
publisher SAGE Publishing
series Pulmonary Circulation
issn 2045-8940
publishDate 2018-06-01
description Crosstalk signaling between the closely juxtaposed epithelial and endothelial membranes of pulmonary alveoli establishes the lung’s immune defense against inhaled and blood-borne pathogens. The crosstalk can occur in a forward direction, as from alveolus to capillary, or in a reverse direction, as from capillary to alveolus. The crosstalk direction likely depends on the site at which pathogens first initiate signaling. Thus, forward crosstalk may occur when inhaled pathogens encounter the alveolar epithelium, while reverse crosstalk may result from interactions of blood-borne pathogens with the endothelium. Here, we review the factors that regulate these two directions of signaling.
url https://doi.org/10.1177/2045894018783735
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AT sunitabhattacharya crosstalksignalingbetweenalveoliandcapillaries
AT jaharbhattacharya crosstalksignalingbetweenalveoliandcapillaries
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