Proteome-wide dataset supporting functional study of tyrosine kinases in breast cancer

Proteome-wide dataset supporting functional study of tyrosine kinases in breast cancer

Tyrosine kinases (TKs) play an essential role in regulating various cellular activities and dysregulation of TK signaling contributes to oncogenesis. However, less than half of the TKs have been thoroughly studied. Through a combined use of RNAi and stable isotope labeling with amino acids in cell c...

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Main Authors: Nicos Angelopoulos, Justin Stebbing, Yichen Xu, Georgios Giamas, Hua Zhang
Format: Article
Language:English
Published: Elsevier 2016-06-01
Series:Data in Brief
Online Access:http://www.sciencedirect.com/science/article/pii/S2352340916301329
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spelling doaj-0975c39c76d14b21aac2eabaf1342f162020-11-24T22:00:22ZengElsevierData in Brief2352-34092016-06-017740746Proteome-wide dataset supporting functional study of tyrosine kinases in breast cancerNicos Angelopoulos0Justin Stebbing1Yichen Xu2Georgios Giamas3Hua Zhang4Department of Surgery and Cancer, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 ONN, UKDepartment of Surgery and Cancer, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 ONN, UKDepartment of Surgery and Cancer, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 ONN, UKDepartment of Surgery and Cancer, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 ONN, UK; School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9RQ, UK; Corresponding author at: Department of Surgery and Cancer, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 ONN, UK.Department of Surgery and Cancer, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 ONN, UK; Corresponding author.Tyrosine kinases (TKs) play an essential role in regulating various cellular activities and dysregulation of TK signaling contributes to oncogenesis. However, less than half of the TKs have been thoroughly studied. Through a combined use of RNAi and stable isotope labeling with amino acids in cell culture (SILAC)-based quantitative proteomics, a global functional proteomic landscape of TKs in breast cancer was recently revealed highlighting a comprehensive and highly integrated signaling network regulated by TKs (Stebbing et al., 2015) [1]. We collate the enormous amount of the proteomic data in an open access platform, providing a valuable resource for studying the function of TKs in cancer and benefiting the science community. Here we present a detailed description related to this study (Stebbing et al., 2015) [1] and the raw data have been deposited to the ProteomeXchange Consortium via the PRIDE partner repository with the identifier http://www.ebi.ac.uk/pride/archive/projects/PXD002065. Keywords: Breast cancer, Cell signaling, Proteomics, SILAC, Tyrosine kinaseshttp://www.sciencedirect.com/science/article/pii/S2352340916301329
collection DOAJ
language English
format Article
sources DOAJ
author Nicos Angelopoulos
Justin Stebbing
Yichen Xu
Georgios Giamas
Hua Zhang
spellingShingle Nicos Angelopoulos
Justin Stebbing
Yichen Xu
Georgios Giamas
Hua Zhang
Proteome-wide dataset supporting functional study of tyrosine kinases in breast cancer
Data in Brief
author_facet Nicos Angelopoulos
Justin Stebbing
Yichen Xu
Georgios Giamas
Hua Zhang
author_sort Nicos Angelopoulos
title Proteome-wide dataset supporting functional study of tyrosine kinases in breast cancer
title_short Proteome-wide dataset supporting functional study of tyrosine kinases in breast cancer
title_full Proteome-wide dataset supporting functional study of tyrosine kinases in breast cancer
title_fullStr Proteome-wide dataset supporting functional study of tyrosine kinases in breast cancer
title_full_unstemmed Proteome-wide dataset supporting functional study of tyrosine kinases in breast cancer
title_sort proteome-wide dataset supporting functional study of tyrosine kinases in breast cancer
publisher Elsevier
series Data in Brief
issn 2352-3409
publishDate 2016-06-01
description Tyrosine kinases (TKs) play an essential role in regulating various cellular activities and dysregulation of TK signaling contributes to oncogenesis. However, less than half of the TKs have been thoroughly studied. Through a combined use of RNAi and stable isotope labeling with amino acids in cell culture (SILAC)-based quantitative proteomics, a global functional proteomic landscape of TKs in breast cancer was recently revealed highlighting a comprehensive and highly integrated signaling network regulated by TKs (Stebbing et al., 2015) [1]. We collate the enormous amount of the proteomic data in an open access platform, providing a valuable resource for studying the function of TKs in cancer and benefiting the science community. Here we present a detailed description related to this study (Stebbing et al., 2015) [1] and the raw data have been deposited to the ProteomeXchange Consortium via the PRIDE partner repository with the identifier http://www.ebi.ac.uk/pride/archive/projects/PXD002065. Keywords: Breast cancer, Cell signaling, Proteomics, SILAC, Tyrosine kinases
url http://www.sciencedirect.com/science/article/pii/S2352340916301329
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AT justinstebbing proteomewidedatasetsupportingfunctionalstudyoftyrosinekinasesinbreastcancer
AT yichenxu proteomewidedatasetsupportingfunctionalstudyoftyrosinekinasesinbreastcancer
AT georgiosgiamas proteomewidedatasetsupportingfunctionalstudyoftyrosinekinasesinbreastcancer
AT huazhang proteomewidedatasetsupportingfunctionalstudyoftyrosinekinasesinbreastcancer
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