THE FEATURES OF SURFACE PHENOTYPE OF BLOOD LYMPHOCYTES IN THE PATIENTS WITH TUBERCULOSIS

• Main Authors: V. V. Novicky, A. K. Strelis, O. I. Urazova, O. V. Voronkova, V. A. Sinitsina, S. B. Tkachenko, O. V. Filiniuk, N. A. Zemlianaya, T. A. Shil’ko, I. Ye. Esimova
• Format: Article
• Language: Russian
• Published: SPb RAACI 2014-07-01
• Series: Medicinskaâ Immunologiâ
• Subjects: tuberculosis; drug-resistant strains; drug-sensitive strains; lymphocytes; lymphocytes subpopulations
• Online Access: http://mimmun.ru/index.php/mimmun/article/view/634
• ISSN: 1563-0625; 2313-741X

<strong>Abstract. </strong>Parameters of peripheral blood lymphocytes subpopulations have been studies in the patients with extensive destructive pulmonary tuberculosis caused by drug-sensitive or drug-resistant Mycobacterium tuberculosis before and in the course of specific anti-tuberculosis chemotherapy. It was revealed that in the patients before treatment, a marked immunosuppression takes place, being characterized by decrease of total T-lymphocytes and their basic regulatory and effector subpopulations. E.e., an increase in CD20+-, CD25+- and CD95+cells was observed. The completion of intensive anti-tuberculosis chemotherapy is not accompanied by correction of lymphocyte subpopulations. By contrary, in the patients with drug-sensitive pulmonary tuberculosis M. tuberculosis a sharp increase in CD95+-lymphocytes is registered. After undergoing a full course of therapy a well-noted tendency to normalization of T-lymphocytes (CD3+) quantity, as well as is regulatory populations (CD4+ and CD8+) were found. The level of CD95+-lymphocytes remained increased in the patients with pulmonary tuberculosis caused by drug-resistant M. tuberculosis.