B-cell depletion is protective against anti-AAV capsid immune response: a human subject case study

B-cell depletion is protective against anti-AAV capsid immune response: a human subject case study

Gene therapy strategies for congenital myopathies may require repeat administration of adeno-associated viral (AAV) vectors due to aspects of the clinical application, such as: (i) administration of doses below therapeutic efficacy in patients enrolled in early phase clinical trials; (ii) progressiv...

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Bibliographic Details
Main Authors: M Corti, ME Elder, DJ Falk, L Lawson, BK Smith, S Nayak, TJ Conlon, N Clément, K Erger, E Lavassani, MM Green, PA Doerfler, RW Herzog, BJ Byrne
Format: Article
Language:English
Published: Elsevier 2014-01-01
Series:Molecular Therapy: Methods & Clinical Development
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050116301000

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