Importance of EMT Factor ZEB1 in cDC1 “MutuDC Line” Mediated Induction of Th1 Immune Response

Importance of EMT Factor ZEB1 in cDC1 “MutuDC Line” Mediated Induction of Th1 Immune Response

The role of Epithelial to Mesenchymal Transition (EMT) factor Zeb1 is well defined in metastasis and cancer progression but it's importance in dendritic cells (DCs) is unexplored until now. For the first time we report here that Zeb1 controls immunogenic responses of CD8α+ conventional Type-I (...

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Bibliographic Details
Main Authors: Shuchi Smita, Abdul Ahad, Arup Ghosh, Viplov K. Biswas, Marianna M. Koga, Bhawna Gupta, Hans Acha-Orbea, Sunil K. Raghav
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Immunology
Subjects:
ZEB1
cDC1 dendritic cells
integrative genomics
Th2 response
ChIP-seq
RNA-seq
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02604/full

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