ATP induces NO production in hippocampal neurons by P2X(7) receptor activation independent of glutamate signaling.

To assess the putative role of adenosine triphosphate (ATP) upon nitric oxide (NO) production in the hippocampus, we used as a model both rat hippocampal slices and isolated hippocampal neurons in culture, lacking glial cells. In hippocampal slices, additions of exogenous ATP or 2'(3')-O-(...

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Bibliographic Details
Main Authors: Juan Francisco Codocedo, Juan Alejandro Godoy, Maria Ines Poblete, Nibaldo C Inestrosa, Juan Pablo Huidobro-Toro
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3589399?pdf=render