Prothrombotic state in patients with metabolic syndrome: an association with inflammation

• Main Authors: V V Kaliuzhin, O F Sibireva, I D Bespalova, E V Kaliuzhina, L M Tkalich, T A Milovanova, I A Osikhov, B Iu Murashev
• Format: Article
• Language: Russian
• Published: "Consilium Medicum" Publishing house 2013-10-01
• Series: Терапевтический архив
• Subjects: metabolic syndrome; prothrombotic state; cytokines
• Online Access: https://ter-arkhiv.ru/0040-3660/article/view/31326

AIM: To comprehensively study hemostasis pathology and its association with the laboratory markers and mediators of inflammation in patients with metabolic syndrome (MS)/MATERIAL AND METHODS: One hundred and eleven patients with type 2 diabetes mellitus, who were diagnosed as having MS, were examined. Vascular-platelet and secondary hemostases and anticoagulant and fibrinolytic systems were evaluated, by performing the complete clinical, laboratory, and instrumental study accepted in a specialized endocrinology clinic. The blood concentrations of high-sensitivity C-reactive protein and proinflammatory cytokines were determined in all the patients with MS and control persons (n=50)/RESULTS: It was found that in patients with MS, hemostasis pathology that might be classified as the combined form of a prethrombotic state, which was caused by different types of a constellation of vascular-platelet and plasma hemostases, as well as physiological anticoagulant deficiency, was linked to the laboratory markers and mediators of subclinical inflammation/CONCLUSION: In the patients with MS, subclinical systemic inflammation is of substantial importance for the mechanisms of a prethrombotic state.