The Transcriptomic Response of the Murine Thyroid Gland to Iodide Overload and the Role of the Nrf2 Antioxidant System

The Transcriptomic Response of the Murine Thyroid Gland to Iodide Overload and the Role of the Nrf2 Antioxidant System

Background: Thyroid follicular cells have physiologically high levels of reactive oxygen species because oxidation of iodide is essential for the iodination of thyroglobulin (Tg) during thyroid hormone synthesis. Thyroid follicles (the functional units of the thyroid) also utilize incompletely under...

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Bibliographic Details
Main Authors: Dionysios V. Chartoumpekis, Panos G. Ziros, Ilias Georgakopoulos-Soares, Adam A. T. Smith, Ana Claudia Marques, Mark Ibberson, Peter A. Kopp, Ioannis Habeos, Ioannis P. Trougakos, Nicholas K. H. Khoo, Gerasimos P. Sykiotis
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Antioxidants
Subjects:
Kelch-like ECH-associated protein 1 (Keap1)
Nfe2l2
RNA-Seq
iodine
oxidative stress
inflammation
Online Access:https://www.mdpi.com/2076-3921/9/9/884

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