TGF-β Signaling Is Necessary and Sufficient for Pharyngeal Arch Artery Angioblast Formation

TGF-β Signaling Is Necessary and Sufficient for Pharyngeal Arch Artery Angioblast Formation

The pharyngeal arch arteries (PAAs) are transient embryonic blood vessels that mature into critical segments of the aortic arch and its branches. Although defects in PAA development cause life-threating congenital cardiovascular defects, the molecular mechanisms that orchestrate PAA morphogenesis re...

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Bibliographic Details
Main Authors: Maryline Abrial, Noëlle Paffett-Lugassy, Spencer Jeffrey, Daniel Jordan, Evan O’Loughlin, Charles J. Frederick, III, C. Geoffrey Burns, Caroline E. Burns
Format: Article
Language:English
Published: Elsevier 2017-07-01
Series:Cell Reports
Subjects:
TGF-β
small-molecule screen
zebrafish
great vessels
pharyngeal arch artery
nkx2.5
cardiovascular
Smad
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717309397

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http://www.sciencedirect.com/science/article/pii/S2211124717309397

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