Intermittent Hypoxia and Hypercapnia, a Hallmark of Obstructive Sleep Apnea, Alters the Gut Microbiome and Metabolome

Intermittent Hypoxia and Hypercapnia, a Hallmark of Obstructive Sleep Apnea, Alters the Gut Microbiome and Metabolome

Intestinal dysbiosis mediates various cardiovascular diseases comorbid with OSA. To understand the role of dysbiosis in cardiovascular and metabolic disease caused by OSA, we systematically study the effect of intermittent hypoxic/hypercapnic stress (IHH, mimicking OSA) on gut microbes in an animal...

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Bibliographic Details
Main Authors: Anupriya Tripathi, Alexey V. Melnik, Jin Xue, Orit Poulsen, Michael J. Meehan, Gregory Humphrey, Lingjing Jiang, Gail Ackermann, Daniel McDonald, Dan Zhou, Rob Knight, Pieter C. Dorrestein, Gabriel G. Haddad
Format: Article
Language:English
Published: American Society for Microbiology 2018-06-01
Series:mSystems
Subjects:
cardiovascular
metabolism
microbiome
sleep apnea
Online Access:https://doi.org/10.1128/mSystems.00020-18

Internet

https://doi.org/10.1128/mSystems.00020-18

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