PML nuclear body biogenesis and oligomerization-driven leukemogenesis

PML nuclear body biogenesis and oligomerization-driven leukemogenesis

Abstract. PML nuclear bodies (NBs), which are increasingly recognized as the central hub of many cellular signaling events, are superassembled spherical complexes with diameters of 0.1–2 μm. Recent studies reveal that RING tetramerization and B1-box polymerization are key factors to the overall PML...

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Main Authors: Yuwen Li, Xiaodan Ma, Guoyu Meng
Format: Article
Language:English
Published: Wolters Kluwer Health 2020-01-01
Series:Blood Science
Online Access:http://journals.lww.com/10.1097/BS9.0000000000000034
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spelling doaj-09343ed61f5049cda4ff287f1bd5b63e2021-01-21T02:41:19ZengWolters Kluwer HealthBlood Science2543-63682020-01-012171010.1097/BS9.0000000000000034202001000-00002PML nuclear body biogenesis and oligomerization-driven leukemogenesisYuwen Li0Xiaodan Ma1Guoyu Meng2State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui-Jin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, ChinaState Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui-Jin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, ChinaState Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui-Jin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, ChinaAbstract. PML nuclear bodies (NBs), which are increasingly recognized as the central hub of many cellular signaling events, are superassembled spherical complexes with diameters of 0.1–2 μm. Recent studies reveal that RING tetramerization and B1-box polymerization are key factors to the overall PML NBs assembly. The productive RBCC oligomerization allows subsequent PML biogenesis steps, including the PML auto-sumoylation and partners recruitment via SUMO–SIM interactions. In promyelocytic leukemia, the oncoprotein PML/RARα (P/R) inhibits PML NBs assembly and leads to a full-fledged leukemogenesis. In this review, we review the recent progress in PML and acute promyelocytic leukemia fields, highlighting the protein oligomerization as an important direction of future targeted therapy.http://journals.lww.com/10.1097/BS9.0000000000000034
collection DOAJ
language English
format Article
sources DOAJ
author Yuwen Li
Xiaodan Ma
Guoyu Meng
spellingShingle Yuwen Li
Xiaodan Ma
Guoyu Meng
PML nuclear body biogenesis and oligomerization-driven leukemogenesis
Blood Science
author_facet Yuwen Li
Xiaodan Ma
Guoyu Meng
author_sort Yuwen Li
title PML nuclear body biogenesis and oligomerization-driven leukemogenesis
title_short PML nuclear body biogenesis and oligomerization-driven leukemogenesis
title_full PML nuclear body biogenesis and oligomerization-driven leukemogenesis
title_fullStr PML nuclear body biogenesis and oligomerization-driven leukemogenesis
title_full_unstemmed PML nuclear body biogenesis and oligomerization-driven leukemogenesis
title_sort pml nuclear body biogenesis and oligomerization-driven leukemogenesis
publisher Wolters Kluwer Health
series Blood Science
issn 2543-6368
publishDate 2020-01-01
description Abstract. PML nuclear bodies (NBs), which are increasingly recognized as the central hub of many cellular signaling events, are superassembled spherical complexes with diameters of 0.1–2 μm. Recent studies reveal that RING tetramerization and B1-box polymerization are key factors to the overall PML NBs assembly. The productive RBCC oligomerization allows subsequent PML biogenesis steps, including the PML auto-sumoylation and partners recruitment via SUMO–SIM interactions. In promyelocytic leukemia, the oncoprotein PML/RARα (P/R) inhibits PML NBs assembly and leads to a full-fledged leukemogenesis. In this review, we review the recent progress in PML and acute promyelocytic leukemia fields, highlighting the protein oligomerization as an important direction of future targeted therapy.
url http://journals.lww.com/10.1097/BS9.0000000000000034
work_keys_str_mv AT yuwenli pmlnuclearbodybiogenesisandoligomerizationdrivenleukemogenesis
AT xiaodanma pmlnuclearbodybiogenesisandoligomerizationdrivenleukemogenesis
AT guoyumeng pmlnuclearbodybiogenesisandoligomerizationdrivenleukemogenesis
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